Abstract
Immunological studies were performed on 12 patients with rheumatoid arthritis who developed reactions to gold. IgE levels were found to be raised in 10 of 11 patients tested at the time of the gold reaction, returning to normal on stopping therapy. Two of 12 patients with gold reactions had positive in-vitro lymphocyte transformation responses to gold.
It is suggested that dermatological side effects in particular are mediated by a type I hypersensitivity response.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baenkler H. W., Scheiffarth F. Lymphozytentransformation und Immunglobuline unter Goldbehandlung. Z Rheumaforsch. 1971 Jul-Aug;30(7):236–239. [PubMed] [Google Scholar]
- Denman E. J., Denman A. M. The lymphocyte transformation test and gold hypersensitivity. Ann Rheum Dis. 1968 Nov;27(6):582–589. doi: 10.1136/ard.27.6.582. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ezeoke A., Perera A. B., Hobbs J. R. Serum IgE elevation with tropical eosinophilia. Clin Allergy. 1973 Mar;3(1):33–35. doi: 10.1111/j.1365-2222.1973.tb01306.x. [DOI] [PubMed] [Google Scholar]
- HUNTER W. M., GREENWOOD F. C. Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature. 1962 May 5;194:495–496. doi: 10.1038/194495a0. [DOI] [PubMed] [Google Scholar]
- Persellin R. H., Hess E. V., Ziff M. Effect of a gold salt on the immune response. Arthritis Rheum. 1967 Apr;10(2):99–106. doi: 10.1002/art.1780100204. [DOI] [PubMed] [Google Scholar]
- Rowe D. S., Anderson S. G., Grab B. A research standard for human serum immunoglobulins IgG, IgA and IgM. Bull World Health Organ. 1970;42(4):535–552. [PMC free article] [PubMed] [Google Scholar]
- Sarkany I. Lymphocyte transformation in drug hypersensitivity. Lancet. 1967 Apr 8;1(7493):743–745. doi: 10.1016/s0140-6736(67)91362-1. [DOI] [PubMed] [Google Scholar]
- Vischer T. L. Lymphocyte cultures in drug hypersensitivity. Lancet. 1966 Aug 27;2(7461):467–469. doi: 10.1016/s0140-6736(66)92773-5. [DOI] [PubMed] [Google Scholar]
- Walzer R. A., Feinstein R., Shapiro L., Einbinder J. Severe hypersensitivity reaction to gold. Positive lymphocyte transformation test. Arch Dermatol. 1972 Aug;106(2):231–234. [PubMed] [Google Scholar]