Abstract
The antigenicity of the two growth phases of Candida albicans has been compared by using crossed immunoelectrophoresis and double-diffusion techniques. Qualitative and quantitative differences in antigenic composition between the phases have been revealed and moreover a specific mycelial antigenic component demonstrated.
It is postulated that the use of specific mycelial antigens for routine diagnostic precipitin testing in patients with suspected systemic candidiasis would give more reliable results than at present obtained with yeast cell antigens.
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- Axelsen N. H., Bock E. Identification and quantitation of antigens and antibodies by means of quantitative immunoelectrophoresis. A survey of methods. J Immunol Methods. 1972 Jan;1(2):109–121. doi: 10.1016/0022-1759(72)90038-5. [DOI] [PubMed] [Google Scholar]
- Chattaway F. W., Holmes M. R., Barlow A. J. Cell wall composition of the mycelial and blastospore forms of Candida albicans. J Gen Microbiol. 1968 May;51(3):367–376. doi: 10.1099/00221287-51-3-367. [DOI] [PubMed] [Google Scholar]
- Dabrowa N., Howard D. H., Landau J. W., Shechter Y. Synthesis of nueic acids and proteins in the dimorphic forms of Candida albicans. Sabouraudia. 1970 Nov;8(3):163–169. doi: 10.1080/00362177085190831. [DOI] [PubMed] [Google Scholar]
- Dastidar S. G. Studies on nucleic acids and protein contents of Candida albicans and their relationship to dimorphism. Indian J Exp Biol. 1966 Jan;4(1):51–52. [PubMed] [Google Scholar]
- KOZINN P. J., TASCHDJIAN C. L. Enteric candidiasis. Diagnosis and clinical considerations. Pediatrics. 1962 Jul;30:71–85. [PubMed] [Google Scholar]
- LAURELL C. B. ANTIGEN-ANTIBODY CROSSED ELECTROPHORESIS. Anal Biochem. 1965 Feb;10:358–361. doi: 10.1016/0003-2697(65)90278-2. [DOI] [PubMed] [Google Scholar]
- MARPLES M. J. Microbiological studies in Western Samoa. II. The isolation of yeast-like organisms from the mouth, with a note of some dermatophytes isolated from lesions of tinea corporis. Trans R Soc Trop Med Hyg. 1960 Mar;54:166–170. doi: 10.1016/0035-9203(60)90053-5. [DOI] [PubMed] [Google Scholar]
- Murray I. G., Buckley H. R., Turner G. C. Serological evidence of Candida infection after open-heart surgery. J Med Microbiol. 1969 Nov 4;2(4):463–469. doi: 10.1099/00222615-2-4-463. [DOI] [PubMed] [Google Scholar]