Abstract
Cell-mediated immune responses to a protein fraction of human bile have been demonstrated, using the leucocyte migration test, in eight out of 10 patients with primary biliary cirrhosis but in only three out of nine with active chronic hepatitis. In the latter condition sensitization to a liver-specific hepatocellular antigen was found more frequently (five out of nine patients) than in primary biliary cirrhosis (two out of 10). These results, as well as the granuloma formation observed histologically, suggest that the initial bile duct lesion in primary biliary cirrhosis may be associated with a cell-mediated response to antigens—perhaps derived from bile duct epithelial cells—which may be normal constituents of hepatic bile.
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- Brown P. C., Glynn L. E., Holborow E. J. The dual necessity for delayed hypersensitivity and circulating antibody in the pathogenesis of experimental allergic orchitis in guinea-pigs. Immunology. 1967 Sep;13(3):307–314. [PMC free article] [PubMed] [Google Scholar]
- Dannenberg A. M., Jr, Meyer O. T., Esterly J. R., Kambara T. The local nature of immunity in tuberculosis, illustrated histochemically in dermal BCG lesions. J Immunol. 1968 May;100(5):931–941. [PubMed] [Google Scholar]
- Doniach D. The concept of an 'autoallergic' hepatitis. Proc R Soc Med. 1970 May;63(5):527–531. [PMC free article] [PubMed] [Google Scholar]
- Dudley F. J., Giustino V., Sherlock S. Cell-mediated immunity in patients positive for hepatitis-associated antigen. Br Med J. 1972 Dec 30;4(5843):754–756. doi: 10.1136/bmj.4.5843.754. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eddleston A. L., Smith M. G., Mitchell C. G., Williams R. Application of the leucocyte migration test to the diagnosis of rejection after liver transplantation. Transplantation. 1971 Jul;12(1):11–17. doi: 10.1097/00007890-197107000-00002. [DOI] [PubMed] [Google Scholar]
- Federlin K., Maini R. N., Russell A. S., Dumonde D. C. A micro-method for peripheral leucocyte migration in tuberculin sensitivity. J Clin Pathol. 1971 Sep;24(6):533–536. doi: 10.1136/jcp.24.6.533. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HARDWICKE J., RANKIN J. G., BAKER K. J., PREISIG R. THE LOSS OF PROTEIN IN HUMAN AND CANINE HEPATIC BILE. Clin Sci. 1964 Jun;26:509–517. [PubMed] [Google Scholar]
- Miller J., Smith M. G., Mitchell C. G., Reed W. D., Eddleston A. L., Williams R. Cell-mediated immunity to a human liver-specific antigen in patients with active chronic hepatitis and primary biliary cirrhosis. Lancet. 1972 Aug 12;2(7772):296–297. doi: 10.1016/s0140-6736(72)92904-2. [DOI] [PubMed] [Google Scholar]
- Mitchell C. G., Smith M. G., Golding P. L., Eddleston A. L., Williams R. Evaluation of the leucocyte migration test as a measure of delayed hypersensitivty in man. Suppression of migration inhibition by puromycin. Clin Exp Immunol. 1972 Aug;11(4):535–541. [PMC free article] [PubMed] [Google Scholar]
- Sherlock S., Fox R. A., James D. G., Scheuer P. J., Sharma O. Impaired delayed hypersensitivity in primary biliary cirrhosis. Lancet. 1969 May 10;1(7602):959–962. doi: 10.1016/s0140-6736(69)91860-1. [DOI] [PubMed] [Google Scholar]
- Smith M. G., Golding P. L., Eddleston A. L., Mitchell C. G., Kemp A., Williams R. Cell-mediated immune responses in chronic liver diseases. Br Med J. 1972 Feb 26;1(5799):527–530. doi: 10.1136/bmj.1.5799.527. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Soborg M., Bendixen G. Human lymphocyte migration as a parameter of hypersensitivity. Acta Med Scand. 1967 Feb;181(2):247–256. doi: 10.1111/j.0954-6820.1967.tb07255.x. [DOI] [PubMed] [Google Scholar]