Abstract
Hyperinfection with Strongyloides stercoralis occurred in three patients with malignant lymphoma. The probable cause in each case was alteration of the immune responses either as a result of the malignant lymphoma or by the treatment given. Though thiabendazole (Mintezol) has produced reasonable results in the treatment of the hyperinfection syndrome, preliminary data suggest that the new broad-spectrum anthelmintic levamisole (Ketrax) is more effective. All patients who live or have lived in an area where strongyloidiasis is endemic should be investigated to detect the presence of the nematode before and during treatment with drugs with immunosuppressive properties. In view of the high mortality with S. stercoralis hyperinfection, vigorous therapy should be instituted before the use of immunosuppressive drugs.
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- BRAS G., RICHARDS R. C., IRVINE R. A., MILNER P. F., RAGBEER M. M. INFECTION WITH STRONGYLOIDES STERCORALIS IN JAMAICA. Lancet. 1964 Dec 12;2(7372):1257–1260. doi: 10.1016/s0140-6736(64)92734-5. [DOI] [PubMed] [Google Scholar]
- Fagundas L. A., Busato O., Brentano L. Strongyloidiasis: fatal complication of renal transplantation. Lancet. 1971 Aug 21;2(7721):439–440. doi: 10.1016/s0140-6736(71)90158-9. [DOI] [PubMed] [Google Scholar]
- Harley J. P., Gallicchio V. Effect of cortisone on the establishment of Nippostrongylus brasiliensis in the rabbit. J Parasitol. 1970 Apr;56(2):271–276. [PubMed] [Google Scholar]
- Louisy C. L., Barton C. J. The radiological diagnosis of Strongyloides stercoralis enteritis. Radiology. 1971 Mar;98(3):535–541. doi: 10.1148/98.3.535. [DOI] [PubMed] [Google Scholar]
- Ogilvie B. M. Use of cortisone derivatives to inhibit resistance to Nippostrongylus brasiliensis and to study the fate of parasites in resistant hosts. Parasitology. 1965 Nov;55(4):723–730. [PubMed] [Google Scholar]
- Rivera E., Maldonado N., Vélez-García E., Grillo A. J., Malaret G. Hyperinfection syndrome with Strongyloides stercoralis. Ann Intern Med. 1970 Feb;72(2):199–204. doi: 10.7326/0003-4819-72-2-199. [DOI] [PubMed] [Google Scholar]
- Rogers W. A., Jr, Nelson B. Strongyloidiasis and malignant lymphoma. "Opportunistic infection" by a nematode. JAMA. 1966 Feb 21;195(8):685–687. [PubMed] [Google Scholar]
- WILSON S., THOMPSON A. E. A FATAL CASE OF STRONGYLOIDIASIS. J Pathol Bacteriol. 1964 Jan;87:169–176. doi: 10.1002/path.1700870123. [DOI] [PubMed] [Google Scholar]
- Yim Y., Kikkawa Y., Tanowitz H., Wittner M. Fatal strongyloidiasis in Hodgkin's disease after immunosuppressive therapy. J Trop Med Hyg. 1970 Oct;73(10):245–249. [PubMed] [Google Scholar]