Skip to main content
British Medical Journal logoLink to British Medical Journal
. 1973 Feb 17;1(5850):386–389. doi: 10.1136/bmj.1.5850.386

Specificity of Serum Creatine Kinase Isoenzymes in Diagnosis of Acute Myocardial Infarction

A Konttinen, H Somer
PMCID: PMC1588287  PMID: 4691060

Abstract

A study of the diagnostic value of serum creatine kinase (CK) isoenzymes showed that MB isoenzyme, which characterizes heart tissue, was a specific and sensitive indicator of acute myocardial infarction. In cases where the clinical picture was complicated by ventricular tachycardia, severe congestive failure, shock, or resuscitation procedures heart, liver, and muscle enzymes were increased. There was also an increase in lactate dehydrogenase isoenzyme values in these cases; indeed, the only enzyme test that correlated well with electrocardiographic and necropsy findings was the MB isoenzyme.

Full text

PDF
386

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COLOMBO J. P., RICHTERICH R., ROSSI E. [Serum creatine phosphokinase: determination and diagnostic significance]. Klin Wochenschr. 1962 Jan 1;40:37–44. doi: 10.1007/BF01483449. [DOI] [PubMed] [Google Scholar]
  2. Dubo H., Park D. C., Pennington R. J., Kalbag R. M., Walton J. N. Serum-creatine-kinase in cases of stroke, head injury, and meningitis. Lancet. 1967 Oct 7;2(7519):743–748. doi: 10.1016/s0140-6736(67)91946-0. [DOI] [PubMed] [Google Scholar]
  3. ELLIOTT B. A., WILKINSON J. H. Serum "alpha-hydroxybutyric dehydrogenase" in myocardial infarction and in liver disease. Lancet. 1961 Apr 1;1(7179):698–699. doi: 10.1016/s0140-6736(61)91724-x. [DOI] [PubMed] [Google Scholar]
  4. Konttinen A., Hupli V., Louhija A., Härtel G. Origin of elevated serum enzyme activities after direct-current countershock. N Engl J Med. 1969 Jul 31;281(5):231–234. doi: 10.1056/NEJM196907312810502. [DOI] [PubMed] [Google Scholar]
  5. Konttinen A., Härtel G., Louhija A. Multiple serum enzyme analyses in chronic alcoholics. Acta Med Scand. 1970 Oct;188(4):257–264. doi: 10.1111/j.0954-6820.1970.tb08034.x. [DOI] [PubMed] [Google Scholar]
  6. Konttinen A., Somer H. Determination of serum creatine kinase isoenzymes in myocardial infarction. Am J Cardiol. 1972 Jun;29(6):817–820. doi: 10.1016/0002-9149(72)90501-2. [DOI] [PubMed] [Google Scholar]
  7. PERLOFF J. K. THE RECOGNITION OF STRICTLY POSTERIOR MYOCARDIAL INFARCTION BY CONVENTIONAL SCALAR ELECTROCARDIOGRAPHY. Circulation. 1964 Nov;30:706–718. doi: 10.1161/01.cir.30.5.706. [DOI] [PubMed] [Google Scholar]
  8. Perkoff G. T. Demonstration of creating phosphokinase in human lung tissue. Arch Intern Med. 1968 Oct;122(4):326–328. [PubMed] [Google Scholar]
  9. REICHARD H. Ornithine carbamyl transferase activity in human tissue homogenates. J Lab Clin Med. 1960 Aug;56:218–221. [PubMed] [Google Scholar]
  10. Smith A. F. Diagnostic value of serum-creatine-kinase in coronary-care unit. Lancet. 1967 Jul 22;2(7508):178–182. doi: 10.1016/s0140-6736(67)90005-0. [DOI] [PubMed] [Google Scholar]
  11. Somer H., Konttinen A. A method allowing the quantitation of serum creatine kinase isoenzymes. Clin Chim Acta. 1972 Feb;36(2):531–536. doi: 10.1016/0009-8981(72)90030-7. [DOI] [PubMed] [Google Scholar]
  12. Somer H., Konttinen A. Demonstration of serum creatine kinase isoenzymes by fluorescence technique. Clin Chim Acta. 1972 Aug;40(1):133–138. doi: 10.1016/0009-8981(72)90260-4. [DOI] [PubMed] [Google Scholar]
  13. Takahashi K., Ushikubo S., Oimomi M., Shinko T. Creatiine phosphokinase isoenzymes of human heart muscle and skeletal muscle. Clin Chim Acta. 1972 May;38(2):285–290. doi: 10.1016/0009-8981(72)90117-9. [DOI] [PubMed] [Google Scholar]
  14. WIEME R. J., HERPOL J. E. Origin of the lactate dehydrogenase isoenzyme pattern found in the serum of patients having primary muscular dystrophy. Nature. 1962 Apr 21;194:287–288. doi: 10.1038/194287b0. [DOI] [PubMed] [Google Scholar]
  15. van der Veen K. J., Willebrands A. F. Isoenzymes of creatine phosphokinase in tissue extracts and in normal and pathological sera. Clin Chim Acta. 1966 Mar;13(3):312–316. doi: 10.1016/0009-8981(66)90209-9. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES