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. 1973 Jan 6;1(5844):16–19. doi: 10.1136/bmj.1.5844.16

Immunological Studies in Ugandan Patients with Hepatocellular Carcinoma

Aron Primack, Charles L Vogel, Lewellys F Barker
PMCID: PMC1588577  PMID: 4345903

Abstract

Immunological studies were performed on Ugandan patients with hepatocellular carcinoma to test the hypothesis that the high rate of persistence of hepatitis-associated antigen in these patients is the result of defects in host immune response. The responses to 1-chloro-2,4-dinitrobenzene sensitization and to a battery of recall skin test antigens were normal, as was the humoral antibody response to tularaemia antigen. Neither hypogammaglobulinaemia nor specific immunoglobulin deficiencies were found. Thus it appears unlikely that generalized defects in host immune responses can account for the high incidence of persistent hepatitis B virus infection found in Ugandan patients with hepatocellular carcinoma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alpert E., Isselbacher K. J. Hepatitis-associated antigen and hepatoma in the U.S. Lancet. 1971 Nov 13;2(7733):1087–1087. doi: 10.1016/s0140-6736(71)90399-0. [DOI] [PubMed] [Google Scholar]
  2. Amos B., Yunis E. Human leukocyte antigenic specificity HL-A3: frequency of occurrence. Science. 1969 Jul 18;165(3890):300–302. doi: 10.1126/science.165.3890.300. [DOI] [PubMed] [Google Scholar]
  3. Anand S., Malaviya A. N. H.A.A. in primary liver-cell carcinoma. Lancet. 1971 Nov;2(7732):1032–1033. doi: 10.1016/s0140-6736(71)90345-x. [DOI] [PubMed] [Google Scholar]
  4. Blumberg B. S., Friedlaender J. S., Woodside A., Sutnick A. I., London W. T. Hepatitis and Australia antigen: autosomal recessive inheritance of susceptibility to infection in humans. Proc Natl Acad Sci U S A. 1969 Apr;62(4):1108–1115. doi: 10.1073/pnas.62.4.1108. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bluming A. Z., Vogel C. L., Ziegler J. L., Mody N., Kamya G. Immunological effects of BCG in malignant melanoma: two modes of administration compared. Ann Intern Med. 1972 Mar;76(3):405–411. doi: 10.7326/0003-4819-76-3-405. [DOI] [PubMed] [Google Scholar]
  6. Denison E. K., Peters R. L., Reynolds T. B. Familial hepatoma with hepatitis-associated antigen. Ann Intern Med. 1971 Mar;74(3):391–394. doi: 10.7326/0003-4819-74-3-391. [DOI] [PubMed] [Google Scholar]
  7. GRABAR P. The use of immunochemical methods in studies on proteins. Adv Protein Chem. 1958;13:1–33. doi: 10.1016/s0065-3233(08)60597-5. [DOI] [PubMed] [Google Scholar]
  8. Gocke D. J., Howe C. Rapid detection of Australia antigen by counterimmunoelectrophoresis. J Immunol. 1970 Apr;104(4):1031–1034. [PubMed] [Google Scholar]
  9. Hadziyannis S. J., Merikas G. E., Afroudakis A. P. Hepatitis-associated antigen in chronic liver disease. Lancet. 1970 Jul 11;1(7663):100–100. doi: 10.1016/s0140-6736(70)92672-3. [DOI] [PubMed] [Google Scholar]
  10. Okochi K., Murakami S. Observations on Australia antigen in Japanese. Vox Sang. 1968;15(5):374–385. doi: 10.1111/j.1423-0410.1968.tb04078.x. [DOI] [PubMed] [Google Scholar]
  11. Prince A. M., Leblanc L., Krohn K., Masseyeff R., Alpert M. E. S.H. antigen and chronic liver disease. Lancet. 1970 Oct 3;2(7675):717–718. doi: 10.1016/s0140-6736(70)91981-1. [DOI] [PubMed] [Google Scholar]
  12. Sherlock S., Fox R. A., Niazi S. P., Scheuer P. J. Chronic liver disease and primary liver-cell cancer with hepatitis-associated (Australia) antigen in serum. Lancet. 1970 Jun 13;1(7659):1243–1247. doi: 10.1016/s0140-6736(70)91737-x. [DOI] [PubMed] [Google Scholar]
  13. Smith J. B., Blumberg B. S. Viral hepatitis, postnecrotic cirrhosis, and hepatocellular carcinoma. Lancet. 1969 Nov 1;2(7627):953–953. doi: 10.1016/s0140-6736(69)90604-7. [DOI] [PubMed] [Google Scholar]
  14. Sutnick A. I., London W. T., Blumberg B. S. Effects of host and environment on immunoglobulins in Down's syndrome. Arch Intern Med. 1969 Dec;124(6):722–725. [PubMed] [Google Scholar]
  15. Sutnick A. I., London W. T., Blumberg B. S., Yankee R. A., Gerstley B. J., Millman I. Australia antigen (a hepatitis-associated antigen) in leukemia. J Natl Cancer Inst. 1970 Jun;44(6):1241–1249. [PubMed] [Google Scholar]
  16. Terés J., Guardia J., Bruguera M., Rodes J. Hepatitis-associated antigen and hepatocellular carcinoma. Lancet. 1971 Jul 24;2(7717):215–215. doi: 10.1016/s0140-6736(71)90926-3. [DOI] [PubMed] [Google Scholar]
  17. Tong M. J., Sun S. C., Schaeffer B. T., Chang N. K., Lo K. J., Peters R. L. Hepatitis-associated antigen and hepatocellular carcinoma in Taiwan. Ann Intern Med. 1971 Nov;75(5):687–691. doi: 10.7326/0003-4819-75-5-687. [DOI] [PubMed] [Google Scholar]
  18. Vogel C. L., Anthony P. P., Mody N., Barker L. F. Hepatitis-associated antigen in Ugandan patients with hepatocellular carcinoma. Lancet. 1970 Sep 26;2(7674):621–624. doi: 10.1016/s0140-6736(70)91396-6. [DOI] [PubMed] [Google Scholar]
  19. Vogel C. L., Anthony P. P., Sadikali F., Barker L. F., Peterson M. R. Hepatitis-associated antigen and antibody in hepatocellular carcinoma: results of a continuing study. J Natl Cancer Inst. 1972 Jun;48(6):1583–1588. [PubMed] [Google Scholar]
  20. Waldorf D. S., Sheagren J. N., Trautman J. R., Block J. B. Impaired delayed hypersensitivity in patients with lepromatous leprosy. Lancet. 1966 Oct 8;2(7467):773–776. doi: 10.1016/s0140-6736(66)90366-7. [DOI] [PubMed] [Google Scholar]
  21. Wright R., McCollum R. W., Klatskin G. Australia antigen in acute and chronic liver disease. Lancet. 1969 Jul 19;2(7612):117–121. doi: 10.1016/s0140-6736(69)92437-4. [DOI] [PubMed] [Google Scholar]
  22. Ziegler J. L., Lewis M. G., Luyombya J. M., Kiryabwire J. W. Immunologic studies in patients with malignant melanoma in Uganda. Br J Cancer. 1969 Dec;23(4):729–734. doi: 10.1038/bjc.1969.89. [DOI] [PMC free article] [PubMed] [Google Scholar]

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