Abstract
Serum triiodothyronine (T-3) concentrations have been estimated by radioimmunoassay using unextracted serum. The serum T-3 concentrations have been shown to be similar in two separate European populations (0·76-1·67 ng/ml). Raised T-3 values have been observed in all subjects with hyperthyroidism. Low values are seen in hypothyroidism although there is some overlap with the normal range. There is a good correlation between serum T-3 and serum thyroxine (T-4) concentrations, and estimation of T-3 seems likely to prove a practical and reliable test of thyroid function.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brown B. L., Ekins R. P., Ellis S. M., Reith W. S. Specific antibodies to triiodothyronine hormone. Nature. 1970 Apr 25;226(5243):359–359. doi: 10.1038/226359a0. [DOI] [PubMed] [Google Scholar]
- Chopra I. J., Solomon D. H., Beall G. N. Radioimmunoassay for measurement of triiodothyronine in human serum. J Clin Invest. 1971 Oct;50(10):2033–2041. doi: 10.1172/JCI106696. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Evered D., Hall R. Hypothyroidism. Br Med J. 1972 Jan 29;1(5795):290–293. doi: 10.1136/bmj.1.5795.290. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GROSS J., PITT-RIVERS R. The identification of 3:5:3'-L-triiodothyronine in human plasma. Lancet. 1952 Mar 1;1(6705):439–441. doi: 10.1016/s0140-6736(52)91952-1. [DOI] [PubMed] [Google Scholar]
- Hesch R. D., Hüfner M. Highly specific antibodies to triiodothyronine. Acta Biol Med Ger. 1972;28(5):861–864. [PubMed] [Google Scholar]
- Larsen P. R. Direct immunoassay of triiodothyronine in human serum. J Clin Invest. 1972 Aug;51(8):1939–1949. doi: 10.1172/JCI107000. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Larsen P. R. Inhibition of triiodothyronine (T3) binding to thyroxine-binding globulin by sodium salicylate and its application to immunoassay of T3 in human serum. Metabolism. 1971 Oct;20(10):976–980. doi: 10.1016/0026-0495(71)90018-7. [DOI] [PubMed] [Google Scholar]
- Larsen P. R. Salicylate-induced increases in free triiodothyronine in human serum. Evidence of inhibition of triiodothyronine binding to thyroxine-binding globulin and thyroxine-binding prealbumin. J Clin Invest. 1972 May;51(5):1125–1134. doi: 10.1172/JCI106905. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Larsen P. R. Technical aspects of the estimation of triiodothyronine in human serum: evidence of conversion of thyroxine to triiodothyronine during assay. Metabolism. 1971 Jun;20(6):609–624. doi: 10.1016/0026-0495(71)90009-6. [DOI] [PubMed] [Google Scholar]
- Mitsuma T., Nihei N., Gershengorn M. C., Hollander C. S. Serum triiodothyronine: measurements in human serum by radioimmunoassay with corroboration by gas-liquid chromatography. J Clin Invest. 1971 Dec;50(12):2679–2688. doi: 10.1172/JCI106769. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ormston B. J., Cryer R. J., Garry R., Besser G. M., Hall R. Thyrotrophin-releasing hormone as a thyroid-function test. Lancet. 1971 Jul 3;2(7714):10–14. doi: 10.1016/s0140-6736(71)90005-5. [DOI] [PubMed] [Google Scholar]
- Sterling K., Bellabarba D., Newman E. S., Brenner M. A. Determination of triiodothyronine concentration in human serum. J Clin Invest. 1969 Jun;48(6):1150–1158. doi: 10.1172/JCI106072. [DOI] [PMC free article] [PubMed] [Google Scholar]