Abstract
A radiopharmsceutical product, labelled macroaggregates of albumin (M.A.A.), which is in use as a lung scintiscanning agent has been noted to have an affinity for venous thrombi. With this material and an inexpensive portable scintillation detector we have attempted to diagnose and localize thrombi in leg veins. The procedure is performed at the bedside and the result is available in 30 minutes. Thirty-one patients with clinical evidence suggestive of deep venous thrombosis in the legs were studied by the radioisotope method and by phlebography. There was agreement in 18 of 21 legs shown to contain thrombus on phlebography and in 9 of 10 legs shown to be free of thrombosis on phlebography. There was, however, lesser agreement on the site of thrombosis between the two methods. The ease of performing the test combined with the rapidity of obtaining results and accuracy in diagnosis suggests that the test has a clinical application.
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Selected References
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- COON W. W., COLLER F. A. Some epidemiologic considerations of thromboembolism. Surg Gynecol Obstet. 1959 Oct;109:487–501. [PubMed] [Google Scholar]
- Duffy G. J., DeNardo G. L., Abington R. B. Origin and evolution of radioactive pulmonary emboli in man. Radiology. 1968 Dec;91(6):1175–1180. doi: 10.1148/91.6.1175. [DOI] [PubMed] [Google Scholar]
- Evans D. S. The early diagnosis of deep-vein thrombosis by ultrasound. Br J Surg. 1970 Oct;57(10):726–728. doi: 10.1002/bjs.1800571008. [DOI] [PubMed] [Google Scholar]
- Flanc C., Kakkar V. V., Clarke M. B. The detection of venous thrombosis of the legs using 125-I-labelled fibrinogen. Br J Surg. 1968 Oct;55(10):742–747. doi: 10.1002/bjs.1800551007. [DOI] [PubMed] [Google Scholar]
- Kakkar V. V., Howe C. T., Flanc C., Clarke M. B. Natural history of postoperative deep-vein thrombosis. Lancet. 1969 Aug 2;2(7614):230–232. doi: 10.1016/s0140-6736(69)90002-6. [DOI] [PubMed] [Google Scholar]
- Mavor G. E., Walker M. G., Dhall D. P., Mahaffy R. G., Duthie J. S., Gaddie J., Reid G. F. Peripheral venous scanning with 125I-tagged fibrinogen. Lancet. 1972 Mar 25;1(7752):661–663. doi: 10.1016/s0140-6736(72)90463-1. [DOI] [PubMed] [Google Scholar]
- Nicolaides A. N., Kakkar V. V., Field E. S., Renney J. T. The origin of deep vein thrombosis: a venographic study. Br J Radiol. 1971 Sep;44(525):653–663. doi: 10.1259/0007-1285-44-525-653. [DOI] [PubMed] [Google Scholar]
- Rosenthall L., Greyson N. D. Observations on the use of 99mTc albumin macroaggregates for detection of thrombophlebitis. Radiology. 1970 Feb;94(2):413–416. doi: 10.1148/94.2.413. [DOI] [PubMed] [Google Scholar]