Abstract
Of 16 steroid-dependent asthmatic patients oral treatment has been discontinued in six and reduced in four after the introduction of beclomethasone dipropionate. Substitution of inhaled beclomethasone for oral steroids was unsuccessful in the remaining six patients. Serial adrenal function studies in the patients whose oral treatment was discontinued showed progressive recovery, and five out of six had a normal response to tetracosactrin stimulation after two months.
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- Brown H. M., Storey G., George W. H. Beclomethasone dipropionate: a new steroid aerosol for the treatment of allergic asthma. Br Med J. 1972 Mar 4;1(5800):585–590. doi: 10.1136/bmj.1.5800.585. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Choo-Kang Y. F., Cooper E. J., Tribe A. E., Grant I. W. Beclomethasone dipropionate by inhalation in the treatment of airways obstruction. Br J Dis Chest. 1972 Apr;66(2):101–106. [PubMed] [Google Scholar]
- Greig W. R., Maxwell J. D., Boyle J. A., Lindsay R. M., Browning M. C. Criteria for distinguishing normal from subnormal adrenocortical function using the Synacthen test. Postgrad Med J. 1969 May;45(523):307–313. doi: 10.1136/pgmj.45.523.307. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LINDER W. R. ADRENAL SUPPRESSION BY AEROSOL STEROID INHALATION. Arch Intern Med. 1964 May;113:655–656. doi: 10.1001/archinte.1964.00280110035006. [DOI] [PubMed] [Google Scholar]
- Lal S., Harris D. M., Bhalla K. K., Singhal S. N., Butler A. G. Comparison of beclomethasone dipropionate aerosol and prednisolone in reversible airways obstruction. Br Med J. 1972 Aug 5;3(5822):314–317. doi: 10.1136/bmj.3.5822.314. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Murphy B. E. Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. J Clin Endocrinol Metab. 1967 Jul;27(7):973–990. doi: 10.1210/jcem-27-7-973. [DOI] [PubMed] [Google Scholar]
- Raffle E. J., Frain-Bell W. The effect of topically applied beclamethasone dipropionate on adrenal function. Br J Dermatol. 1967 Aug-Sep;79(8):487–490. doi: 10.1111/j.1365-2133.1967.tb11536.x. [DOI] [PubMed] [Google Scholar]
- Scoggins R. B., Kliman B. Percutaneous absorption of corticosteroids: systemic effects. N Engl J Med. 1965 Oct 14;273(16):831–840. doi: 10.1056/NEJM196510142731601. [DOI] [PubMed] [Google Scholar]
- Westerhof L., Van Ditmars M. J., Der Kinderen P. J., Thijssen J. H., Schwarz F. Recovery of adrenocortical function during long-term treatment with corticosteroids. Br Med J. 1972 Apr 22;2(5807):195–197. doi: 10.1136/bmj.2.5807.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Westerhof L., van Ditmars M. J., Kinderen PJ der, Thijssen J. H., Schwarz F. Recovery of adrenocortical function during long-term treatment with corticosteroids. Br Med J. 1970 Nov 28;4(5734):534–537. doi: 10.1136/bmj.4.5734.534. [DOI] [PMC free article] [PubMed] [Google Scholar]