Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1973 Apr 14;2(5858):80–82. doi: 10.1136/bmj.2.5858.80

Placental Lactogen Levels in Diabetic Pregnancy

W Ursell, M Brudenell, T Chard
PMCID: PMC1589073  PMID: 4700328

Abstract

A prospective study has been carried out of placental lactogen levels in pregnancy complicated by diabetes mellitus. The levels were higher than those in normal pregnant subjects; the higher levels were related to increased placental and fetal weight but more closely to the former; and lower levels were found when there was clinical evidence of placental dysfunction. Those patients requiring the largest insulin increment for the control of their diabetes in the pregnancy have placental lactogen levels in the higher range.

Full text

PDF
80

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beck P., Daughaday W. H. Human placental lactogen: studies of its acute metabolic effects and disposition in normal man. J Clin Invest. 1967 Jan;46(1):103–110. doi: 10.1172/JCI105503. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beck P., Parker M. L., Daughaday W. H. Radioimmunologic measurement of human placental lactogen in plasma by a double antibody method during normal and diabetic pregnancies. J Clin Endocrinol Metab. 1965 Nov;25(11):1457–1462. doi: 10.1210/jcem-25-11-1457. [DOI] [PubMed] [Google Scholar]
  3. Brudenell M., Beard R. Diabetes in pregnancy. Clin Endocrinol Metab. 1972 Nov;1(3):673–695. doi: 10.1016/s0300-595x(72)80039-2. [DOI] [PubMed] [Google Scholar]
  4. Costrini N. V., Kalkhoff R. K. Relative effects of pregnancy, estradiol, and progesterone on plasma insulin and pancreatic islet insulin secretion. J Clin Invest. 1971 May;50(5):992–999. doi: 10.1172/JCI106593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Genazzani A. R., Cocola F., Casoli M., Mello G., Scarselli G., Neri P., Fioretti P. Human chorionic somatomammotrophin radioimmunoassay in evaluation of placental function. J Obstet Gynaecol Br Commonw. 1971 Jul;78(7):577–589. doi: 10.1111/j.1471-0528.1971.tb00320.x. [DOI] [PubMed] [Google Scholar]
  6. Grumbach M. M., Kaplan S. L., Abrams C. L., Bell J. J., Conte F. A. Plasma free fatty acid response to the administration of chorionic "growth hormone-prolactin". J Clin Endocrinol Metab. 1966 Apr;26(4):478–482. doi: 10.1210/jcem-26-4-478. [DOI] [PubMed] [Google Scholar]
  7. Haour F., Cohen M., Bertrand J. Radioimmunoassay of human chorionic somatomammatropin (HCS) plasma levels in normal and abnormal pregnancies. Rev Eur Etud Clin Biol. 1971 Feb;16(2):124–130. [PubMed] [Google Scholar]
  8. Josimovich J. B., Kosor B., Boccella L., Mintz D. H., Hutchinson D. L. Placental lactogen in maternal serum as an index of fetal health. Obstet Gynecol. 1970 Aug;36(2):244–250. [PubMed] [Google Scholar]
  9. Kalkhoff R. K., Jacobson M., Lemper D. Progesterone, pregnancy and the augmented plasma insulin response. J Clin Endocrinol Metab. 1970 Jul;31(1):24–28. doi: 10.1210/jcem-31-1-24. [DOI] [PubMed] [Google Scholar]
  10. Kalkhoff R. K., Richardson B. L., Beck P. Relative effects of pregnancy, human placental lactogen and prednisolone on carbohydrate tolerance in normal and subclinical diabetic subjects. Diabetes. 1969 Mar;18(3):153–163. doi: 10.2337/diab.18.3.153. [DOI] [PubMed] [Google Scholar]
  11. Letchworth A. T., Boardman R. J., Bristow C., Landon J., Chard T. A rapid semi-automated method for the measurement of human chorionic somatomammotrophin. The normal range in the third trimester and its relation to fetal weight. J Obstet Gynaecol Br Commonw. 1971 Jun;78(6):542–548. doi: 10.1111/j.1471-0528.1971.tb00313.x. [DOI] [PubMed] [Google Scholar]
  12. Letchworth A. T., Chard T. Human placental lactogen levels in pre-eclampsia. J Obstet Gynaecol Br Commonw. 1972 Aug;79(8):680–683. doi: 10.1111/j.1471-0528.1972.tb12900.x. [DOI] [PubMed] [Google Scholar]
  13. Letchworth A. T., Chard T. Placental lactogen levels as a screening test for fetal distress and neonatal asphyxia. Lancet. 1972 Apr 1;1(7753):704–706. doi: 10.1016/s0140-6736(72)90227-9. [DOI] [PubMed] [Google Scholar]
  14. Samaan N., Yen S. C., Gonzalez D., Pearson O. H. Metabolic effects of placental lactogen (HPL) in man. J Clin Endocrinol Metab. 1968 Apr;28(4):485–491. doi: 10.1210/jcem-28-4-485. [DOI] [PubMed] [Google Scholar]
  15. Saxena B. N., Emerson K., Jr, Selenkow H. A. Serum placental lactogen (HPL) levels as an index of placental function. N Engl J Med. 1969 Jul 31;281(5):225–231. doi: 10.1056/NEJM196907312810501. [DOI] [PubMed] [Google Scholar]
  16. Selenkow H. A., Varma K., Younger D., White P., Emerson K., Jr Patterns of serum immunoreactive human placental lactogen (IR-HPL) and chorionic gonadotropin (IR-HCG) in diabetic pregnancy. Diabetes. 1971 Oct;20(10):696–706. doi: 10.2337/diab.20.10.696. [DOI] [PubMed] [Google Scholar]
  17. Singer W., Desjardins P., Friesen H. G. Human placental lactogen. An index of placental function. Obstet Gynecol. 1970 Aug;36(2):222–232. [PubMed] [Google Scholar]
  18. Spellacy W. N., Teoh E. S., Buhi W. C., Birk S. A., McCreary S. A. Value of human chorionic somatomammotropin in managing high-risk pregnancies. Am J Obstet Gynecol. 1971 Feb 15;109(4):588–598. doi: 10.1016/0002-9378(71)90634-x. [DOI] [PubMed] [Google Scholar]
  19. Spona J., Janisch H. Serum placental lactogen (HPL) as index of placental function. Acta Endocrinol (Copenh) 1971 Oct;68(2):401–412. doi: 10.1530/acta.0.0680401. [DOI] [PubMed] [Google Scholar]
  20. Zuckerman J. E., Fallon V., Tashjian A. H., Jr, Levine L., Friesen H. G. Rapid, quantitative estimation of human placental lactogen in maternal serum by complement fixation. J Clin Endocrinol Metab. 1970 Jun;30(6):769–773. doi: 10.1210/jcem-30-6-769. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES