Skip to main content
British Medical Journal logoLink to British Medical Journal
. 1973 Apr 14;2(5858):82–84. doi: 10.1136/bmj.2.5858.82

Clinical and Laboratory Double-blind Investigation on Effect of Fibrinolytic Therapy in Patients with Cutaneous Vasculitis

B Dodman, W J Cunliffe, B E Roberts, R Sibbald
PMCID: PMC1589113  PMID: 4573315

Abstract

The effects of phenformin and ethyloestrenol and phenformin and stanozolol on the clinical state, plasma fibrinolytic activity, and fibrinogen-fibrin-related antigen (F.R.-antigen) were compared with placebo in 13 patients with cutaneous vasculitis. Eight patients showed considerable clinical improvement when taking phenformin and an anabolic steroid; an impaired fibrinolytic activity before treatment favoured clinical improvement.

Full text

PDF
82

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cochrane C. G. The role of immune complexes and complement in tissue injury. J Allergy. 1968 Sep;42(3):113–129. doi: 10.1016/0021-8707(68)90085-3. [DOI] [PubMed] [Google Scholar]
  2. Cunliffe W. J., Menon I. S. The association between cutaneous vasculitis and decreased blood fibrinolytic activity. Br J Dermatol. 1971 Feb;84(2):99–105. doi: 10.1111/j.1365-2133.1971.tb06850.x. [DOI] [PubMed] [Google Scholar]
  3. Fearnley G. R., Chakrabarti R., Evans J. F. Fibrinolytic and defibrinating effect of phenformin plus ethyloestrenol in vivo. Lancet. 1969 May 3;1(7601):910–914. doi: 10.1016/s0140-6736(69)92545-8. [DOI] [PubMed] [Google Scholar]
  4. Gallimore M. J., Tyler H. M., Shaw J. T. The origin of fibrin breakdown products and the interpretation of their appearance in the circulation. J Clin Pathol. 1972 Mar;25(3):185–190. doi: 10.1136/jcp.25.3.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gormsen J. Fibrinolytic activity and haemagglutination inhibition immunoassays. Scand J Haematol. 1970;7(4):261–273. doi: 10.1111/j.1600-0609.1970.tb01897.x. [DOI] [PubMed] [Google Scholar]
  6. Isacson S., Linell F., Möller H., Nilsson I. M. Coagulation and fibrinolysis in chronic panniculitis. Acta Derm Venereol. 1970;50(3):213–217. [PubMed] [Google Scholar]
  7. Katz D. H., Unanue E. R., Dixon F. J. Introduction of intravascular coagulation and focal tissue necrosis in rats by administration of anti-connective tissue antibodies. Am J Pathol. 1968 Nov;53(5):835–850. [PMC free article] [PubMed] [Google Scholar]
  8. Kurban A. K., Ryan T. J. Fibrinogen titre, fibrinolysis and platelet stickiness correlated with capillary bleeding or block in the skin. Trans St Johns Hosp Dermatol Soc. 1969;55(2):218–222. [PubMed] [Google Scholar]
  9. Merskey C., Kleiner G. J., Johnson A. J. Quantitative estimation of split products of fibrinogen in human serum, relation to diagnosis and treatment. Blood. 1966 Jul;28(1):1–18. [PubMed] [Google Scholar]
  10. Parish W. E. Cutaneous vasculitis: antigen-antibody complexes and prolonged fibrinolysis. Proc R Soc Med. 1972 Mar;65(3):276–278. doi: 10.1177/003591577206500323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Strauss A. J., Snell K. C., Duntley B. J., Soban E. J., Stewart H. L. Spontaneous thymoma, polymyositis, and serum-autoantibodies to striated muscle in the rodent, subgenus Praomys (Mastomys) natalensis. Similarities to thymoma with myasthenia gravis in man. Lancet. 1968 May 25;1(7552):1126–1129. doi: 10.1016/s0140-6736(68)90189-x. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES