Abstract
Plasma renin levels, measured in 39 untreated patients in 1967, under conditions of sodium loading and sodium depletion have been related to the incidence of stroke and myocardial infarction. Renin levels were not significantly different in patients with or without vascular complications. Out of 13 patients with persistently low renin levels 6 had suffered either a stroke or a myocardial infarction and 7 had not. Plasma renin levels were also measured in 116 treated hypertensive patients. There was no relation between plasma renin level and vascular complications. It is concluded that levels of plasma renin are not a reliable index of the probability of hypertensive patients suffering a stroke or myocardial infarction.
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- Breckenridge A., Dollery C. T., Parry E. H. Prognosis of treated hypertension. Changes in life expectancy and causes of death between 1952 and 1967. Q J Med. 1970 Jul;39(155):411–429. [PubMed] [Google Scholar]
- Brunner H. R., Laragh J. H., Baer L., Newton M. A., Goodwin F. T., Krakoff L. R., Bard R. H., Bühler F. R. Essential hypertension: renin and aldosterone, heart attack and stroke. N Engl J Med. 1972 Mar 2;286(9):441–449. doi: 10.1056/NEJM197203022860901. [DOI] [PubMed] [Google Scholar]
- Creditor M. C., Loschky U. K. Incidence of suppressed renin activity and of normokalemic primary aldosteronism in hypertensive Negro patients. Circulation. 1968 Jun;37(6):1027–1031. doi: 10.1161/01.cir.37.6.1027. [DOI] [PubMed] [Google Scholar]
- Helmer O. M., Judson W. E. Metabolic studies on hypertensive patients with suppressed plasma renin activity not due to hyperaldosternosm. Circulation. 1968 Nov;38(5):965–976. doi: 10.1161/01.cir.38.5.965. [DOI] [PubMed] [Google Scholar]
- Jerums G., Doyle A. E. Renal sodium handling and responsiveness of plasma renin levels in hypertension. Clin Sci. 1969 Aug;37(1):79–90. [PubMed] [Google Scholar]
- Mendelsohn F., Hutchinson J., Johnston C. I. A review of plasma renin measurements and their clinical significance. Aust N Z J Med. 1971 Feb;1(1):86–93. doi: 10.1111/j.1445-5994.1971.tb02269.x. [DOI] [PubMed] [Google Scholar]
- Skinner S. L. Improved assay methods for renin "concentration" and "activity" in human plasma. Methods using selective denaturation of renin substrate. Circ Res. 1967 Apr;20(4):391–402. doi: 10.1161/01.res.20.4.391. [DOI] [PubMed] [Google Scholar]