Skip to main content
NCBI home page
British Medical Journal logoLink to British Medical Journal
. 1973 May 26;2(5864):452–455. doi: 10.1136/bmj.2.5864.452

Systemic Lupus Erythematosus Syndrome Induced by Practolol

E B Raftery, A M Denman
PMCID: PMC1589475  PMID: 4145853

Abstract

Three patients with angina pectoris treated with practolol in varying doses developed a syndrome of arthralgia, particularly of the small joints of the hands, rash, fever, a raised E.S.R., and positive tests for lupus erythematosus (L.E.) cells and antinuclear antibody. The syndrome responded partly to withdrawal of the drug, but steroids were required to produce adequate symptomatic improvement. These disease features suggest that this is an example of drug-induced systemic lupus erythematosus (S.L.E.). The impaired ability of lymphocytes from these patients to transform in vitro indicates a testable hypothesis for the pathogenesis of the syndrome.

Full text

PDF
452

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alarcón-Segovia D. Drug-induced lupus syndromes. Mayo Clin Proc. 1969 Sep;44(9):664–681. [PubMed] [Google Scholar]
  2. Allison A. C., Denman A. M., Barnes R. D. Cooperating and controlling functions of thymus-derived lymphocytes in relation to autoimmunity. Lancet. 1971 Jul 17;2(7716):135–140. doi: 10.1016/s0140-6736(71)92306-3. [DOI] [PubMed] [Google Scholar]
  3. Dubois E. L. Procainamide induction of a systemic lupus erythematosus-like syndrome. Presentation of six cases, review of the literature, and analysis and followup of reported cases. Medicine (Baltimore) 1969 May;48(3):217–228. [PubMed] [Google Scholar]
  4. Fakhro A. M., Ritchie R. F., Lown B. Lupus-like syndrome induced by procainamide. Am J Cardiol. 1967 Sep;20(3):367–373. doi: 10.1016/0002-9149(67)90060-4. [DOI] [PubMed] [Google Scholar]
  5. Hadden J. W., Hadden E. M., Middleton E., Jr Lymphocyte blast transformation. I. Demonstration of adrenergic receptors in human peripheral lymphocytes. Cell Immunol. 1970 Dec;1(6):583–595. doi: 10.1016/0008-8749(70)90024-9. [DOI] [PubMed] [Google Scholar]
  6. Hosking C. S., Fitzgerald M. G., Simons M. J. Quantified deficiency of lymphocyte response to phytohaemagglutinin in immune deficiency diseases. Clin Exp Immunol. 1971 Oct;9(4):467–476. [PMC free article] [PubMed] [Google Scholar]
  7. Hughes G. R., Cohen S. A., Christian C. L. Anti-DNA activity in systemic lupus erythematosus. A diagnostic and therapeutic guide. Ann Rheum Dis. 1971 May;30(3):259–264. doi: 10.1136/ard.30.3.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hughes G. R. Significance of anti-D.N.A. antibodies in systemic lupus erythematosus. Lancet. 1971 Oct 16;2(7729):861–863. doi: 10.1016/s0140-6736(71)90234-0. [DOI] [PubMed] [Google Scholar]
  9. LADD A. T. Procainamide-induced lupus erythematosus. N Engl J Med. 1962 Dec 27;267:1357–1358. doi: 10.1056/NEJM196212272672608. [DOI] [PubMed] [Google Scholar]
  10. Perrudet-Badoux A., Frei P. C. Detection of antibodies on blood lymphocytes in drug hypersensitivity using a rosette technique. Int Arch Allergy Appl Immunol. 1971;41(1):149–156. doi: 10.1159/000230508. [DOI] [PubMed] [Google Scholar]
  11. Russell A. S., Ziff M. Natural antibodies to procaine amide. Clin Exp Immunol. 1968 Nov;3(9):901–909. [PMC free article] [PubMed] [Google Scholar]
  12. Sorrell T. C., Forbes I. J., Burness F. R., Rischbieth R. H. Depression of immunological function in patients treated with phenytoin sodium (sodium diphenylhydantoin). Lancet. 1971 Dec 4;2(7736):1233–1235. doi: 10.1016/s0140-6736(71)90547-2. [DOI] [PubMed] [Google Scholar]
  13. Strom T. B., Deisseroth A., Morganroth J., Carpenter C. B., Merrill J. P. Alteration of the cytotoxic action of sensitized lymphocytes by cholinergic agents and activators of adenylate cyclase. Proc Natl Acad Sci U S A. 1972 Oct;69(10):2995–2999. doi: 10.1073/pnas.69.10.2995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Swarbrick E. T., Gray I. R. Systemic lupus erythematosus during treatment with procainamide. Br Heart J. 1972 Mar;34(3):284–288. doi: 10.1136/hrt.34.3.284. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. WILSKE K. R., SHALIT I. E., WILLKENS R. F., DECKER J. L. FINDINGS SUGGESTIVE OF SYSTEMIC LUPUS ERYTHEMATOSUS IN SUBJECTS ON CHRONIC ANTICONVULSANT THERAPY. Arthritis Rheum. 1965 Apr;8:260–266. doi: 10.1002/art.1780080209. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES