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. 1973 May 19;2(5863):398–400. doi: 10.1136/bmj.2.5863.398

Neurological Disease associated with Folate Deficiency

E H Reynolds, P Rothfeld, Jonathen H Pincus
PMCID: PMC1589924  PMID: 4703098

Abstract

In a general medical hospital population the neurological status of 24 patients with severe folate deficiency was compared with that of a control group of 21 patients with normal serum folate. A significant increase of organic brain syndrome and pyramidal tract damage was found in the folate-deficient group. These findings were independent of the degree of anaemia or the presence of alcoholism. These data are consistent with the view that severe folate deficiency may cause neurological deficits.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahmed M. Neurological disease and folate deficiency. Br Med J. 1972 Jan 15;1(5793):181–181. doi: 10.1136/bmj.1.5793.181-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Arakawa T. Congenital defects in folate utilization. Am J Med. 1970 May;48(5):594–598. doi: 10.1016/0002-9343(70)90009-4. [DOI] [PubMed] [Google Scholar]
  3. Batata M., Spray G. H., Bolton F. G., Higgins G., Wollner L. Blood and bone marrow changes in elderly patients, with special reference to folic acid, vitamin B12, iron, and ascorbic acid. Br Med J. 1967 Jun 10;2(5553):667–669. doi: 10.1136/bmj.2.5553.667. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Grant H. C., Hoffbrand A. V., Wells D. G. Folate deficiency and neurological disease. Lancet. 1965 Oct 16;2(7416):763–767. doi: 10.1016/s0140-6736(65)90813-5. [DOI] [PubMed] [Google Scholar]
  5. Haltia M. The effect of folate deficiency on neuronal RNA content. A quantitative cytochemical study. Br J Exp Pathol. 1970 Apr;51(2):191–196. [PMC free article] [PubMed] [Google Scholar]
  6. Pincus J. H., Reynolds E. H., Glaser G. H. Subacute combined system degeneration with folate deficiency. JAMA. 1972 Jul 31;221(5):496–497. [PubMed] [Google Scholar]
  7. Reynolds E. H., Chanarin I., Milner G., Matthews D. M. Anticonvulsant therapy, folic acid and vitamin B12 metabolism and mental symptoms. Epilepsia. 1966 Dec;7(4):261–270. doi: 10.1111/j.1528-1157.1966.tb03806.x. [DOI] [PubMed] [Google Scholar]
  8. Reynolds E. H., Gallagher B. B., Mattson R. H., Bowers M., Johnson A. L. Relationship between serum and cerebrospinal fluid folate. Nature. 1972 Nov 17;240(5377):155–157. doi: 10.1038/240155a0. [DOI] [PubMed] [Google Scholar]
  9. Strachan R. W., Henderson J. G. Dementia and folate deficiency. Q J Med. 1967 Apr;36(142):189–204. [PubMed] [Google Scholar]
  10. Wells C. E. Clinical neurology of macrocytic anaemia. Proc R Soc Med. 1965 Sep;58(9):721–724. [PMC free article] [PubMed] [Google Scholar]

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