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. 1989 Oct;64(10 Spec No):1379–1383. doi: 10.1136/adc.64.10_spec_no.1379

Chorioamnionitis and serum IgM in Wilson-Mikity syndrome.

M Fujimura 1, T Takeuchi 1, H Kitajima 1, M Nakayama 1
PMCID: PMC1590104  PMID: 2589873

Abstract

A total of 753 infants weighing less than 1800 g at birth were studied prospectively and their serum IgM concentrations measured within 72 hours of age. Placentas from 584 of these infants were examined histologically for chorioamnionitis. The results were correlated with chronic respiratory insufficiency. Altogether 101 infants developed chronic respiratory insufficiency of which 22 had bronchopulmonary dysplasia and 35 Wilson-Mikity syndrome. The remaining 44 infants were classified as 'unexplained chronic lung disease'. Mean serum IgM concentration for Wilson-Mikity syndrome was 1.02 g/l whereas it was 0.14 g/l for bronchopulmonary dysplasia and 0.32 g/l for unexplained chronic lung disease. The incidence of chorioamnionitis was significantly higher in Wilson-Mikity syndrome (30/35) compared with bronchopulmonary dysplasia (4/16) and with infants without chronic respiratory insufficiency (145/490). Wilson-Mikity syndrome was shown to be significantly correlated with the evidences of intrauterine inflammation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aherne W. A., Cross K. W., Hey E. N., Lewis S. R. Lung function and pathology in a premature infant with chronic pulmonary insufficiency (Wilson-Mikity syndrome). Pediatrics. 1967 Dec;40(6):962–974. [PubMed] [Google Scholar]
  2. BAGHDASSARIAN O. M., AVERY M. E., NEUHAUSER E. B. A form of pulmonary insufficiency in premature infants. Pulmonary dysmaturity? Am J Roentgenol Radium Ther Nucl Med. 1963 May;89:1020–1031. [PubMed] [Google Scholar]
  3. BENIRSCHKE K. Routes and types of infection in the fetus and the newborn. AMA J Dis Child. 1960 Jun;99:714–721. doi: 10.1001/archpedi.1960.02070030716003. [DOI] [PubMed] [Google Scholar]
  4. Berg T. Immunoglobulin levels in infants with low birth weights. Acta Paediatr Scand. 1968 Sep;57(5):369–376. doi: 10.1111/j.1651-2227.1968.tb07307.x. [DOI] [PubMed] [Google Scholar]
  5. Coates A. L., Bergsteinsson H., Desmond K., Outerbridge E. W., Beaudry P. H. Long-term pulmonary sequelae of the Wilson-Mikity syndrome. J Pediatr. 1978 Feb;92(2):247–252. doi: 10.1016/s0022-3476(78)80019-5. [DOI] [PubMed] [Google Scholar]
  6. Edwards D. K., Dyer W. M., Northway W. H., Jr Twelve years' experience with bronchopulmonary dysplasia. Pediatrics. 1977 Jun;59(6):839–846. [PubMed] [Google Scholar]
  7. Fujimura M., Takeuchi T., Ando M., Funato M., Shimada S., Tsujimoto A., Kanaya S., Kozuki K., Morinoto S. Elevated immunoglobulin M levels in low birth-weight neonates with chronic respiratory insufficiency. Early Hum Dev. 1983 Dec;9(1):27–32. doi: 10.1016/0378-3782(83)90099-3. [DOI] [PubMed] [Google Scholar]
  8. Hodgman J. E., Mikity V. G., Tatter D., Cleland R. S. Chronic respiratory distress in the premature infant. Wilson-Mikity syndrome. Pediatrics. 1969 Aug;44(2):179–195. [PubMed] [Google Scholar]
  9. Krauss A. N., Levin A. R., Grossman H., Auld P. A. Physiologic studies on infants with Wilson-Mikity syndrome. Ventilation-perfusion abnormalities and cardiac catheterization angiography. J Pediatr. 1970 Jul;77(1):27–36. doi: 10.1016/s0022-3476(70)80041-5. [DOI] [PubMed] [Google Scholar]
  10. Navarro C., Blanc W. A. Subacute necrotizing funisitis. A variant of cord inflammation with a high rate of perinatal infection. J Pediatr. 1974 Nov;85(5):689–697. doi: 10.1016/s0022-3476(74)80521-4. [DOI] [PubMed] [Google Scholar]
  11. Northway W. H., Jr, Rosan R. C., Porter D. Y. Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia. N Engl J Med. 1967 Feb 16;276(7):357–368. doi: 10.1056/NEJM196702162760701. [DOI] [PubMed] [Google Scholar]
  12. Ogden B. E., Murphy S. A., Saunders G. C., Pathak D., Johnson J. D. Neonatal lung neutrophils and elastase/proteinase inhibitor imbalance. Am Rev Respir Dis. 1984 Nov;130(5):817–821. doi: 10.1164/arrd.1984.130.5.817. [DOI] [PubMed] [Google Scholar]
  13. Pattle R. E., Kratzing C. C., Parkinson C. E., Graves L., Robertson R. D., Robards G. J., Currie J. O., Parsons J. H., Sutherland P. D. Maturity of fetal lungs tested by production of stable microbubbles in amniotic fluid. Br J Obstet Gynaecol. 1979 Aug;86(8):615–622. doi: 10.1111/j.1471-0528.1979.tb10823.x. [DOI] [PubMed] [Google Scholar]
  14. Samuels M. P., Warner J. O. Bronchopulmonary dysplasia: the outcome. Arch Dis Child. 1987 Nov;62(11):1099–1101. doi: 10.1136/adc.62.11.1099. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Swyer P. R., Delivoria-Papadopoulos M., Levison H., Reilly B. J., Balis J. U. The pulmonary syndrome of Wilson and Mikity. Pediatrics. 1965 Sep;36(3):374–384. [PubMed] [Google Scholar]
  16. Toce S. S., Farrell P. M., Leavitt L. A., Samuels D. P., Edwards D. K. Clinical and roentgenographic scoring systems for assessing bronchopulmonary dysplasia. Am J Dis Child. 1984 Jun;138(6):581–585. doi: 10.1001/archpedi.1984.02140440065017. [DOI] [PubMed] [Google Scholar]

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