Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1990 Jul;65(7 Spec No):690–691. doi: 10.1136/adc.65.7_spec_no.690

Effect of indomethacin on binding of bilirubin to albumin.

B C Lam 1, H N Wong 1, C Y Yeung 1
PMCID: PMC1590185  PMID: 2386402

Abstract

The effect of indomethacin on the binding of bilirubin to protein was studied in vitro by the horseradish peroxidase oxidation method. Plasma indomethacin concentrations ranging from 1500 micrograms/l to 4500 micrograms/l, which were much higher than the therapeutic concentrations achieved in vivo, were used for the studies. The bilirubin-protein titration curves obtained indicate that indomethacin, although protein bound, does not affect the binding of bilirubin to protein. Our study confirms that it is safe to use conventional doses of indomethacin in jaundiced preterm infants.

Full text

PDF
690

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bhat R., Vidyasagar D., Vadapalli M., Whalley C., Fisher E., Hastreiter A., Evans M. Disposition of indomethacin in preterm infants. J Pediatr. 1979 Aug;95(2):313–316. [PubMed] [Google Scholar]
  2. Friedman C. A., Parks B. R., Rawson J. E., Serwer G. A., Anderson P. A. Indomethacin and the preterm infant with a patent ductus arteriosus: relationship between plasma concentration and ductus closure. Dev Pharmacol Ther. 1982;4(1-2):37–46. doi: 10.1159/000457389. [DOI] [PubMed] [Google Scholar]
  3. Jacobsen J., Wennberg R. P. Determination of unbound bilirubin in the serum of newborns. Clin Chem. 1974 Jul;20(7):783–783. [PubMed] [Google Scholar]
  4. Leonhardt A., Isken V., Kühl P. G., Seyberth H. W. Prolonged indomethacin treatment in preterm infants with symptomatic patent ductus arteriosus: efficacy, drug level monitoring, and patient selection. Eur J Pediatr. 1987 Mar;146(2):140–144. doi: 10.1007/BF02343219. [DOI] [PubMed] [Google Scholar]
  5. Leonhardt A., Isken V., Kühl P. G., Seyberth H. W. Prolonged indomethacin treatment in preterm infants with symptomatic patent ductus arteriosus: efficacy, drug level monitoring, and patient selection. Eur J Pediatr. 1987 Mar;146(2):140–144. doi: 10.1007/BF02343219. [DOI] [PubMed] [Google Scholar]
  6. Mason R. W., McQueen E. G. Protein binding of indomethacin: binding of indomethacin to human plasma albumin and its displacement from binding by ibuprofen, phenylbutazone and salicylate, in vitro. Pharmacology. 1974;12(1):12–19. doi: 10.1159/000136516. [DOI] [PubMed] [Google Scholar]
  7. Nestrud R. M., Hill D. E., Arrington R. W., Beard A. G., Dungan W. T., Lau P. Y., Norton J. B., Readinger R. I. Indomethacin treatment in patent ductus arteriosus. A double-blind study utilizing indomethacin plasma levels. Dev Pharmacol Ther. 1980;1(2-3):125–136. [PubMed] [Google Scholar]
  8. Obeyesekere H. I., Pankhurst S., Yu V. Y. Pharmacological closure of ductus arteriosus in preterm infants using indomethacin. Arch Dis Child. 1980 Apr;55(4):271–276. doi: 10.1136/adc.55.4.271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ramsay J. M., Murphy D. J., Jr, Vick G. W., 3rd, Courtney J. T., Garcia-Prats J. A., Huhta J. C. Response of the patent ductus arteriosus to indomethacin treatment. Am J Dis Child. 1987 Mar;141(3):294–297. doi: 10.1001/archpedi.1987.04460030072028. [DOI] [PubMed] [Google Scholar]
  10. Shankaran S., Pantoja A., Poland R. L. Indomethacin and bilirubin-albumin binding. Dev Pharmacol Ther. 1982;4(3-4):124–131. doi: 10.1159/000457401. [DOI] [PubMed] [Google Scholar]
  11. Vert P., Bianchetti G., Marchal F., Monin P., Morselli P. L. Effectiveness and pharmacokinetics of indomethacin in premature newborns with patent ductus arteriosus. Eur J Clin Pharmacol. 1980 Jul;18(1):83–88. doi: 10.1007/BF00561483. [DOI] [PubMed] [Google Scholar]
  12. Yeh T. F., Luken J. A., Thalji A., Raval D., Carr I., Pildes R. S. Intravenous indomethacin therapy in premature infants with persistent ductus arteriosus--a double-blind controlled study. J Pediatr. 1981 Jan;98(1):137–145. doi: 10.1016/s0022-3476(81)80560-4. [DOI] [PubMed] [Google Scholar]
  13. Zini R., D'Athis P., Barre J., Tillement J. P. Binding of indomethacin to human serum albumin. Its non displacement by various agents, influence of free fatty acids and the unexpected effect of indomethacin on warfarin binding. Biochem Pharmacol. 1979 Sep 1;28(17):2661–2665. doi: 10.1016/0006-2952(79)90043-1. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES