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. 1990 Oct;65(10 Spec No):1038–1042. doi: 10.1136/adc.65.10_spec_no.1038

Spontaneous resolution of bone mineral depletion in preterm infants.

P J Congdon 1, A Horsman 1, S W Ryan 1, J G Truscott 1, H Durward 1
PMCID: PMC1590241  PMID: 2241222

Abstract

Fifteen preterm infants and 17 born at full term whose gestational ages ranged from 25 to 34 weeks and 38 to 42 weeks, respectively, were examined initially at postconceptional ages ranging from 38 to 44 weeks and subsequently at 46 to 71 weeks. Each examination included measurement of bone mineral content of the mid-forearm by single photon absorptiometry. For the preterm group, the mean (SD) value of bone mineral content at the first examination was 109.0 (27.6) mg/cm and was significantly lower than the corresponding value of 194.4 (19.6) mg/cm for the whole full term group. The mean subsequent rate of mineral accretion in the preterm group was 8.70 (4.60) mg/cm/week, the mean individual duration of observation being 9.7 weeks. Rate of mineral accretion for the full term group was independent of the duration of observation and averaged 1.60 (2.20) mg/cm/week. The difference between mean values of rate of mineral accretion in the preterm and full term groups was highly significant. Our results show that there is a phase of rapid mineral accretion starting at 40 weeks' postconception in preterm infants that substantially reduces the perinatal mineralisation deficit.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barltrop D., Oppè T. E. Calcium and fat absorption by low birthweight infants from a calcium-supplemented milk formula. Arch Dis Child. 1973 Aug;48(8):580–582. doi: 10.1136/adc.48.8.580. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Callenbach J. C., Sheehan M. B., Abramson S. J., Hall R. T. Etiologic factors in rickets of very low-birth-weight infants. J Pediatr. 1981 May;98(5):800–805. doi: 10.1016/s0022-3476(81)80852-9. [DOI] [PubMed] [Google Scholar]
  3. Dahlenburg S. L., Bishop N. J., Lucas A. Are preterm infants at risk for subsequent fractures? Arch Dis Child. 1989 Oct;64(10 Spec No):1384–1385. doi: 10.1136/adc.64.10_spec_no.1384. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Day G. M., Chance G. W., Radde I. C., Reilly B. J., Park E., Sheepers J. Growth and mineral metabolism in very low birth weight infants. II. Effects of calcium supplementation on growth and divalent cations. Pediatr Res. 1975 Jul;9(7):568–575. doi: 10.1203/00006450-197507000-00003. [DOI] [PubMed] [Google Scholar]
  5. Gairdner D., Pearson J. A growth chart for premature and other infants. Arch Dis Child. 1971 Dec;46(250):783–787. doi: 10.1136/adc.46.250.783. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gross S. J. Bone mineralization in preterm infants fed human milk with and without mineral supplementation. J Pediatr. 1987 Sep;111(3):450–458. doi: 10.1016/s0022-3476(87)80478-x. [DOI] [PubMed] [Google Scholar]
  7. Helin I., Landin L. A., Nilsson B. E. Bone mineral content in preterm infants at age 4 to 16. Acta Paediatr Scand. 1985 Mar;74(2):264–267. doi: 10.1111/j.1651-2227.1985.tb10962.x. [DOI] [PubMed] [Google Scholar]
  8. Hittner H. M., Hirsch N. J., Rudolph A. J. Assessment of gestational age by examination of the anterior vascular capsule of the lens. J Pediatr. 1977 Sep;91(3):455–458. doi: 10.1016/s0022-3476(77)81324-3. [DOI] [PubMed] [Google Scholar]
  9. Horsman A., Ryan S. W., Congdon P. J., Truscott J. G., James J. R. Osteopenia in extremely low birthweight infants. Arch Dis Child. 1989 Apr;64(4 Spec No):485–488. doi: 10.1136/adc.64.4_spec_no.485. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Horsman A., Ryan S. W., Congdon P. J., Truscott J. G., Simpson M. Bone mineral accretion rate and calcium intake in preterm infants. Arch Dis Child. 1989 Jul;64(7 Spec No):910–918. doi: 10.1136/adc.64.7_spec_no.910. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Horsman A., Ryan S. W., Congdon P. J., Truscott J. G., Simpson M. Bone mineral content and body size 65 to 100 weeks' postconception in preterm and full term infants. Arch Dis Child. 1989 Nov;64(11):1579–1586. doi: 10.1136/adc.64.11.1579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. James J. R., Congdon P. J., Truscott J., Horsman A., Arthur R. Osteopenia of prematurity. Arch Dis Child. 1986 Sep;61(9):871–876. doi: 10.1136/adc.61.9.871. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. James J. R., Truscott J., Congdon P. J., Horsman A. Measurement of bone mineral content in the human fetus by photon absorptiometry. Early Hum Dev. 1986 Apr;13(2):169–181. doi: 10.1016/0378-3782(86)90005-8. [DOI] [PubMed] [Google Scholar]
  14. Kulkarni P. B., Hall R. T., Rhodes P. G., Sheehan M. B., Callenbach J. C., Germann D. R., Abramson S. J. Rickets in very low-birth-weight infants. J Pediatr. 1980 Feb;96(2):249–252. doi: 10.1016/s0022-3476(80)80814-6. [DOI] [PubMed] [Google Scholar]
  15. Markestad T., Aksnes L., Finne P. H., Aarskog D. Plasma concentrations of vitamin D metabolites in premature infants. Pediatr Res. 1984 Mar;18(3):269–272. doi: 10.1203/00006450-198403000-00011. [DOI] [PubMed] [Google Scholar]
  16. Parkin J. M., Hey E. N., Clowes J. S. Rapid assessment of gestational age at birth. Arch Dis Child. 1976 Apr;51(4):259–263. doi: 10.1136/adc.51.4.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Ryan S., Congdon P. J., James J., Truscott J., Horsman A. Mineral accretion in the human fetus. Arch Dis Child. 1988 Jul;63(7):799–808. doi: 10.1136/adc.63.7.799. [DOI] [PMC free article] [PubMed] [Google Scholar]

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