Skip to main content
NCBI home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1992 Oct;67(10 Spec No):1193–1195. doi: 10.1136/adc.67.10_spec_no.1193

Changes in the plasma aminogram of parenterally fed infants treated with dexamethasone for bronchopulmonary dysplasia.

P C Ng 1, K G Brownlee 1, E J Kelly 1, M J Henderson 1, M Smith 1, P R Dear 1
PMCID: PMC1590469  PMID: 1444557

Abstract

A substantial increase in the plasma concentration of most amino acids was observed in 59 preterm infants with chronic lung disease soon after the initiation of dexamethasone therapy. The size of increase appeared to be dose related. This phenomenon is likely to be the result of steroid induced protein catabolism. Interestingly, neither phenylalanine nor tyrosine concentrations were significantly increased.

Full text

PDF
1193

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Björkman O., Lindholm M. Phenylalanine content and total parenteral nutrition. Lancet. 1987 Jun 6;1(8545):1311–1311. doi: 10.1016/s0140-6736(87)90558-7. [DOI] [PubMed] [Google Scholar]
  2. Brownlee K. G., Ng P. C., Henderson M. J., Smith M., Green J. H., Dear P. R. Catabolic effect of dexamethasone in the preterm baby. Arch Dis Child. 1992 Jan;67(1 Spec No):1–4. doi: 10.1136/adc.67.1_spec_no.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Clark D., Henderson M., Smith M., Dear P. R. Plasma amino acid concentrations in parenterally fed preterm infants. Arch Dis Child. 1989 Jul;64(7 Spec No):939–942. doi: 10.1136/adc.64.7_spec_no.939. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cummings J. J., D'Eugenio D. B., Gross S. J. A controlled trial of dexamethasone in preterm infants at high risk for bronchopulmonary dysplasia. N Engl J Med. 1989 Jun 8;320(23):1505–1510. doi: 10.1056/NEJM198906083202301. [DOI] [PubMed] [Google Scholar]
  5. Deutschman C. S., Konstantinides F. N., Raup S., Cerra F. B. Physiological and metabolic response to isolated closed-head injury. Part 2: Effects of steroids on metabolism. Potentiation of protein wasting and abnormalities of substrate utilization. J Neurosurg. 1987 Mar;66(3):388–395. doi: 10.3171/jns.1987.66.3.0388. [DOI] [PubMed] [Google Scholar]
  6. Evans S. J., Wynne-Williams T. C., Russell C. A., Fairbrother A. Hyperphenylalaninaemia in parenterally fed newborn babies. Lancet. 1986 Dec 13;2(8520):1404–1405. doi: 10.1016/s0140-6736(86)92053-2. [DOI] [PubMed] [Google Scholar]
  7. Fajans S. S., Floyd J. C., Jr, Knopf R. F., Conn F. W. Effect of amino acids and proteins on insulin secretion in man. Recent Prog Horm Res. 1967;23:617–662. doi: 10.1016/b978-1-4831-9826-2.50017-9. [DOI] [PubMed] [Google Scholar]
  8. Harkavy K. L., Scanlon J. W., Chowdhry P. K., Grylack L. J. Dexamethasone therapy for chronic lung disease in ventilator- and oxygen-dependent infants: a controlled trial. J Pediatr. 1989 Dec;115(6):979–983. doi: 10.1016/s0022-3476(89)80754-1. [DOI] [PubMed] [Google Scholar]
  9. Hoy W. E., Sargent J. A., Freeman R. B., Pabico R. C., McKenna B. A., Sterling W. A., Jr The influence of glucocorticoid dose on protein catabolism after renal transplantation. Am J Med Sci. 1986 Apr;291(4):241–247. doi: 10.1097/00000441-198604000-00005. [DOI] [PubMed] [Google Scholar]
  10. Kazzi N. J., Brans Y. W., Poland R. L. Dexamethasone effects on the hospital course of infants with bronchopulmonary dysplasia who are dependent on artificial ventilation. Pediatrics. 1990 Nov;86(5):722–727. [PubMed] [Google Scholar]
  11. Seagraves A., Moore E. E., Moore F. A., Weil R., 3rd Net protein catabolic rate after kidney transplantation: impact of corticosteroid immunosuppression. JPEN J Parenter Enteral Nutr. 1986 Sep-Oct;10(5):453–455. doi: 10.1177/0148607186010005453. [DOI] [PubMed] [Google Scholar]
  12. Walker V., Hall M. A., Bulusu S., Allan A. Hyperphenylalaninaemia in parenterally fed newborn babies. Lancet. 1986 Nov 29;2(8518):1284–1284. doi: 10.1016/s0140-6736(86)92715-7. [DOI] [PubMed] [Google Scholar]
  13. Wallenburg H. C., Dekker G. A., Makovitz J. W., Rotmans P. Low-dose aspirin prevents pregnancy-induced hypertension and pre-eclampsia in angiotensin-sensitive primigravidae. Lancet. 1986 Jan 4;1(8471):1–3. doi: 10.1016/s0140-6736(86)91891-x. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES