Abstract
Fifteen extremely low birthweight (ELBW) white infants (those weighing 1000 g or less) were observed at birth, within eight weeks of birth and near 40 weeks postconception. On the second and third occasions, weight, crown-heel length, and bone mineral content of their forearms were measured. Fifteen infants born at full term on whom similar measurements were made soon after birth acted as controls. Between 32 and 39 weeks the median weight of ELBW infants increased from 970 g to 1850 g and crown-heel length from 35.7 cm to 41.0 cm. There was no evidence, however, of bone mineral accretion in the measurement region; initial and final median measurements of bone mineral content were 76 mg/cm and 86 mg/cm, the median individual difference being only 4 mg/cm with an interquartile range of 25 mg/cm. Median weight, crown-heel length, and bone mineral content of the control group were 3270 g, 50.6 cm, and 196 mg/cm, respectively. Compared with the controls, ELBW infants at 39 weeks were a median (interquartile range) of 1420 (525) g lighter, 9.9 (3.9) cm shorter, and had a bone mineral content deficit of 108 (32) mg/cm. In terms of weight and crown-heel length ELBW infants at 39 weeks were comparable with infants born and observed at 32 weeks' gestation; compared with these infants the bone mineral content deficit in the ELBW group was about 33%.
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Selected References
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- Chan G. M., Mileur L., Hansen J. W. Effects of increased calcium and phosphorous formulas and human milk on bone mineralization in preterm infants. J Pediatr Gastroenterol Nutr. 1986 May-Jun;5(3):444–449. doi: 10.1097/00005176-198605000-00019. [DOI] [PubMed] [Google Scholar]
- Greer F. R., Lane J., Weiner S., Mazess R. B. An accurate and reproducible absorptiometric technique for determining bone mineral content in newborn infants. Pediatr Res. 1983 Apr;17(4):259–262. doi: 10.1203/00006450-198304000-00005. [DOI] [PubMed] [Google Scholar]
- Hillman L. S., Hollis B., Salmons S., Martin L., Slatopolsky E., McAlister W., Haddad J. Absorption, dosage, and effect on mineral homeostasis of 25-hydroxycholecalciferol in premature infants: comparison with 400 and 800 IU vitamin D2 supplementation. J Pediatr. 1985 Jun;106(6):981–989. doi: 10.1016/s0022-3476(85)80255-9. [DOI] [PubMed] [Google Scholar]
- Hittner H. M., Hirsch N. J., Rudolph A. J. Assessment of gestational age by examination of the anterior vascular capsule of the lens. J Pediatr. 1977 Sep;91(3):455–458. doi: 10.1016/s0022-3476(77)81324-3. [DOI] [PubMed] [Google Scholar]
- James J. R., Congdon P. J., Truscott J., Horsman A., Arthur R. Osteopenia of prematurity. Arch Dis Child. 1986 Sep;61(9):871–876. doi: 10.1136/adc.61.9.871. [DOI] [PMC free article] [PubMed] [Google Scholar]
- James J. R., Truscott J., Congdon P. J., Horsman A. Measurement of bone mineral content in the human fetus by photon absorptiometry. Early Hum Dev. 1986 Apr;13(2):169–181. doi: 10.1016/0378-3782(86)90005-8. [DOI] [PubMed] [Google Scholar]
- Lyon A. J., McIntosh N., Wheeler K., Williams J. E. Radiological rickets in extremely low birthweight infants. Pediatr Radiol. 1987;17(1):56–58. doi: 10.1007/BF02386596. [DOI] [PubMed] [Google Scholar]
- Parkin J. M., Hey E. N., Clowes J. S. Rapid assessment of gestational age at birth. Arch Dis Child. 1976 Apr;51(4):259–263. doi: 10.1136/adc.51.4.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ryan S., Congdon P. J., James J., Truscott J., Horsman A. Mineral accretion in the human fetus. Arch Dis Child. 1988 Jul;63(7):799–808. doi: 10.1136/adc.63.7.799. [DOI] [PMC free article] [PubMed] [Google Scholar]