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. 1973 Jun 9;2(5866):586–588. doi: 10.1136/bmj.2.5866.586

Hereditary Giant Platelet Syndrome: A Disorder of a New Aspect of Platelet Function

Margaret A Howard, R A Hutton, R M Hardisty
PMCID: PMC1592168  PMID: 4541347

Abstract

The platelets of three patients with the hereditary giant platelet syndrome of Bernard and Soulier failed to aggregate in response to either ristocetin or bovine fibrinogen. The results of aggregation experiments using mixtures of platelets and plasma suggest that a reaction between a plasma factor deficient in von Willebrand's disease and a platelet component lacking in our patients, and leading to platelet aggregation independently of adenosine diphosphate (ADP), is essential for normal haemostasis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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