Abstract
An 11-week crossover study was carried out in which 12 subjects smoked high-nicotine (1·84 mg standard yield) and low-nicotine (0·6 mg) cigarettes after an initial period of smoking their usual brands with a medium-nicotine yield (mean 1·4 mg). Plasma and urine nicotine concentrations, carboxyhaemoglobin (COHb) concentration, puffing behaviour, 24-hour cigarette consumption, and butt nicotine content were measured. The changes in plasma nicotine and blood COHb concentrations showed that the smokers compensated for about two-thirds of the difference in standard yields when switched to either high- or low-nicotine cigarettes. Thus, compared with the medium-nicotine brand, the intake of nicotine and carbon monoxide was only about 10% higher when subjects smoked the high-nicotine cigarettes, which had a standard yield 30-40% higher than the medium brands; and only about 15% lower when they smoked the low-nicotine cigarettes, which had a standard yield about 50% lower than the medium brands. But nicotine content and urine nicotine concentrations followed a similar pattern. Changes in puffing behaviour and in 24-hour cigarette consumption were only slight.
The results show clear evidence of both upward and downward self-titration of nicotine and carbon monoxide (and tar) intakes when smokers change to cigarettes with standard yields that differ over the range studied.
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Selected References
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- Beckett A. H., Triggs E. J. Determination of nicotine and its metabolite, cotinine, in urine by gas chromatography. Nature. 1966 Sep 24;211(5056):1415–1417. doi: 10.1038/2111415a0. [DOI] [PubMed] [Google Scholar]
- Feyerabend C., Russell M. A. Improved gas chromatographic method and micro-extraction technique for the measurement of nicotine in biological fluids. J Pharm Pharmacol. 1979 Feb;31(2):73–76. doi: 10.1111/j.2042-7158.1979.tb13435.x. [DOI] [PubMed] [Google Scholar]
- Freedman S., Fletcher C. M. Changes of smoking habits and cough in men smoking cigarettes with 30% NSM tobacco substitute. Br Med J. 1976 Jun 12;1(6023):1427–1430. doi: 10.1136/bmj.1.6023.1427. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Frith C. D. The effect of varying the nicotine content of cigarettes on human smoking behaviour. Psychopharmacologia. 1971;19(2):188–192. doi: 10.1007/BF00402641. [DOI] [PubMed] [Google Scholar]
- Kozlowski L. T., Jarvik M. E., Gritz E. R. Nicotine regulation and cigarette smoking. Clin Pharmacol Ther. 1975 Jan;17(1):93–97. doi: 10.1002/cpt197517193. [DOI] [PubMed] [Google Scholar]
- Turner J. A., Sillett R. W., Ball K. P. Some effects of changing to low-tar and low-nicotine cigarettes. Lancet. 1974 Sep 28;2(7883):737–739. doi: 10.1016/s0140-6736(74)90938-6. [DOI] [PubMed] [Google Scholar]