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. 1979 Dec 8;2(6203):1466–1468. doi: 10.1136/bmj.2.6203.1466

Effects of indomethacin on postural hypotension in Parkinsonism.

G Abate, R M Polimeni, F Cuccurullo, P Puddu, S Lenzi
PMCID: PMC1597182  PMID: 393356

Abstract

A study was conducted to evaluate the effect of indomethacin on orthostatic hypotension in Parkinsonism. Twelve elderly patients participated and the drug was given in two-ways--as an intravenous infusion of 50 mg over 30 minutes and by mouth 50 mg thrice daily for six days. Results were assessed by measuring the degree of hypotension on standing, response to the cold pressor test, and forearm blood flow (by strain-gauge plethysmography). Indomethacin significantly reduced the fall in blood pressure on standing (P less than 0:001) and lessened or reversed orthostatic symptoms. Furthermore, there was an enhanced response to the cold pressor test and a reduction in forearm blood flow. These findings suggest that indomethacin has a positive effect on systemic vascular resistance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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