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. 1979 Jan 20;1(6157):153–156. doi: 10.1136/bmj.1.6157.153

Characteristics affecting fibrinolytic activity and plasma fibrinogen concentrations.

T W Meade, R Chakrabarti, A P Haines, W R North, Y Stirling
PMCID: PMC1597599  PMID: 420998

Abstract

As part of a study to determine the extent to which the haemostatic system is implicated in the onset of clinically manifest ischaemic heart disease, characteristics influencing fibrinolytic activity (FA) and plasma fibrinogen concentrations were examined in 1601 men aged 18-64 and 707 women aged 18-59 in several occupational groups in North-west London. In men FA noticeably decreased till the age of about 58, when there was a small rise. In women a small increase in FA between 18 and about 40 was followed by a slightly larger fall between 40 and 59. There was a pronounced negative association of FA with obesity. FA was significantly less in smokers than non-smokers, though the effect was not large. FA increased with alcohol consumption. FA in men appeared to be greatest in the lower social classes, and men on night shift had poorer FA than those on day work. FA was greater in women using oral contraceptives than in those not using these preparations. In both sexes FA increased with exercise, but there were no associations between any of the characteristics studied and the increase. Plasma fibrinogen concentrations increase with age and obesity, are higher in smokers than non-smokers, and fall with alcohol consumption. In women the concentrations are higher in those using oral contraceptives. The general epidemiology of FA and plasma fibrinogen concentrations suggests that they may well be implicated in the pathogenesis of ischaemic heart disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett N. B., Ogston C. M., McAndrew G. M., Ogston D. Studies on the fibrinolytic enzyme system in obesity. J Clin Pathol. 1966 May;19(3):241–243. doi: 10.1136/jcp.19.3.241. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Billimoria J. D., Pozner H., Metselaar B., Best F. W., James D. C. Effect of cigarette smoking on lipids, lipoproteins, blood coagulation, fibrinolysis and cellular components of human blood. Atherosclerosis. 1975 Jan-Feb;21(1):61–76. doi: 10.1016/0021-9150(75)90094-5. [DOI] [PubMed] [Google Scholar]
  3. Castelli W. P., Doyle J. T., Gordon T., Hames C. G., Hjortland M. C., Hulley S. B., Kagan A., Zukel W. J. Alcohol and blood lipids. The cooperative lipoprotein phenotyping study. Lancet. 1977 Jul 23;2(8030):153–155. doi: 10.1016/s0140-6736(77)90176-3. [DOI] [PubMed] [Google Scholar]
  4. Chakrabarti R., Hocking E. D., Fearnley G. R., Mann R. D., Attwell T. N., Jackson D. Fibrinolytic activity and coronary-artery disease. Lancet. 1968 May 11;1(7550):987–990. doi: 10.1016/s0140-6736(68)91104-5. [DOI] [PubMed] [Google Scholar]
  5. FEARNLEY G. R., CHAKRABARTI R., AVIS P. R. Blood fibrinolytic activity in diabetes mellitus and its bearing on ischaemic heart disease and obesity. Br Med J. 1963 Apr 6;1(5335):921–923. doi: 10.1136/bmj.1.5335.921. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. FEARNLEY G. R., CHAKRABARTI R. Increase of blood fibrinolytic activity by testosterone. Lancet. 1962 Jul 21;2(7247):128–132. doi: 10.1016/s0140-6736(62)90009-0. [DOI] [PubMed] [Google Scholar]
  7. FEARNLEY G. R., CHAKRABARTI R. PHARMACOLOGICAL ENCHANCEMENT OF FIBRINOLYTIC ACTIVITY OF BLOOD. J Clin Pathol. 1964 May;17:328–332. doi: 10.1136/jcp.17.3.328. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. FEARNLEY G. R., FERGUSON J., CHAKRABARTI R., VINCENT C. T. Effect of beer on blood fibrinolytic activity. Lancet. 1960 Jan 23;1(7117):184–186. doi: 10.1016/s0140-6736(60)90107-0. [DOI] [PubMed] [Google Scholar]
  9. FLUTE P. T. THE ASSESSMENT OF FIBRINOLYTIC ACTIVITY IN THE BLOOD. Br Med Bull. 1964 Sep;20:195–199. doi: 10.1093/oxfordjournals.bmb.a070330. [DOI] [PubMed] [Google Scholar]
  10. Fearnley G. R., Chakrabarti R. Fibrinolytic treatment of rheumatoid arthritis with phenformin plus ethyloestrenol. Lancet. 1966 Oct 8;2(7467):757–761. doi: 10.1016/s0140-6736(66)90360-6. [DOI] [PubMed] [Google Scholar]
  11. Grace C. S., Goldrick R. B. Fibrinolysis and body bulid. Interrelationships between blood fibrinolysis, body composition and parameters of lipid and carbohydrate metabolism. J Atheroscler Res. 1968 Jul-Aug;8(4):705–719. doi: 10.1016/s0368-1319(68)80028-6. [DOI] [PubMed] [Google Scholar]
  12. JOHNSON A. J., McCARTY W. R. The lysis of artificially induced intravascular clots in man by intravenous infusions of streptokinase. J Clin Invest. 1959 Sep;38:1627–1643. doi: 10.1172/JCI103941. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Janzon L., Nilsson I. M. Smoking and fibrinolysis. Circulation. 1975 Jun;51(6):1120–1123. doi: 10.1161/01.cir.51.6.1120. [DOI] [PubMed] [Google Scholar]
  14. Mann R. D. Effect of age, sex, and diurnal variation on the human fibrinolystic system. J Clin Pathol. 1967 May;20(3):223–226. doi: 10.1136/jcp.20.3.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Meade T. W., Brozović M., Chakrabarti R., Haines A. P., North W. R., Stirling Y. Ethnic group comparisons of variables associated with ischaemic heart disease. Br Heart J. 1978 Jul;40(7):789–795. doi: 10.1136/hrt.40.7.789. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Meade T. W., Chakrabarti R., North W. R. Fibrinolytic activity in health and vascular disease. Br Med J. 1977 Mar 26;1(6064):837–837. doi: 10.1136/bmj.1.6064.837. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Meade T. W., North W. R., Chakrabarti R., Haines A. P., Stirling Y. Population-based distributions of haemostatic variables. Br Med Bull. 1977 Sep;33(3):283–288. doi: 10.1093/oxfordjournals.bmb.a071448. [DOI] [PubMed] [Google Scholar]
  18. Modell C. B., Stocks J., Dormandy T. L. Letter: Vitamin E in thalassaemia. Br Med J. 1974 Jul 27;3(5925):259–259. doi: 10.1136/bmj.3.5925.259-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. RIMON A., SEGAL S. STREPTOKINASE-INDUCED PROTEOLYTIC ACTIVITY WITH RESPECT TO AGE IN TWO ETHNIC GROUPS IN ISRAEL. Thromb Diath Haemorrh. 1964 Apr 15;11:119–126. [PubMed] [Google Scholar]
  20. SWAN H. T. Fibrinolysis related to age in men. Br J Haematol. 1963 Jul;9:311–318. doi: 10.1111/j.1365-2141.1963.tb06555.x. [DOI] [PubMed] [Google Scholar]
  21. Warlow C. P., McNeill A., Ogston D., Douglas A. S. Platelet adhesiveness, coagulation, and fibrinolytic activity in obesity. J Clin Pathol. 1972 Jun;25(6):484–486. doi: 10.1136/jcp.25.6.484. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Yano K., Rhoads G. G., Kagan A. Coffee, alcohol and risk of coronary heart disease among Japanese men living in Hawaii. N Engl J Med. 1977 Aug 25;297(8):405–409. doi: 10.1056/NEJM197708252970801. [DOI] [PubMed] [Google Scholar]

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