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. 1979 Mar 10;1(6164):650–652. doi: 10.1136/bmj.1.6164.650

Therapeutic effect of cimetidine in patients undergoing haemodialysis.

R H Jones, M R Lewin, V Parsons
PMCID: PMC1598296  PMID: 435708

Abstract

Blood concentrations of cimetidine were measured and the therapeutic effect of the drug assessed patients undergoing maintenance haemodialysis. Thirteen patients were given a single oral 200-mg dose of cimetidine a mean of 2.7 hours before the start of dialysis. Dialysing for 6--12-6 m2 hours led to a mean fall of 71% in blood cimetidine concentration during haemodialysis. Nine patients with various upper gastrointestinal lesions diagnosed endoscopically were treated for up to six weeks with a reduced cimetidine dose of 200 mg 12-hourly; two patients received two courses of treatment. Repeat endoscopy after treatment disclosed satisfactory healing, and the drug did not accumulate. This lower dose regimen is recommended for patients receiving dialysis who develop upper gastrointestinal lesions for which a histamine H2-receptor antagonist is indicated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bodemar G., Walan A. Cimetidine in the treatment of active duodenal and prepyloric ulcers. Lancet. 1976 Jul 24;2(7978):161–164. doi: 10.1016/s0140-6736(76)92342-4. [DOI] [PubMed] [Google Scholar]
  2. Burland W. L., Duncan W. A., Hesselbo T., Mills J. G., Sharpe P. C., Haggie S. J., Wyllie J. H. Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man. Br J Clin Pharmacol. 1975 Dec;2(6):481–486. doi: 10.1111/j.1365-2125.1975.tb00564.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chisholm G. D., Mee A. D., Williams G., Castro J. E., Baron J. H. Peptic ulceration, gastric secretion, and renal transplantation. Br Med J. 1977 Jun 25;1(6077):1630–1633. doi: 10.1136/bmj.1.6077.1630. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Clendinnen B. G., Reeder D. D., Brandt E. N., Jr, Thompson J. C. Effect of nephrectomy on the rate and pattern of the disappearance of exogenous gastrin in dogs. Gut. 1973 Jun;14(6):462–467. doi: 10.1136/gut.14.6.462. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Doherty C. C., O'Connor F. A., Buchanan K. D., McGeown M. G. Cimetidine for duodenal ulceration in patients undergoing haemodialysis. Br Med J. 1977 Dec 10;2(6101):1506–1508. doi: 10.1136/bmj.2.6101.1506. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Frost F., Rahbek I., Rune S. J., Jensen K. B., Gudmand-Hoyer E., Krag E., Rask-Madsen J., Wulff H. R., Garbol J., Jensen K. G. Cimetidine in patients with gastric ulcer: a multicentre controlled trial. Br Med J. 1977 Sep 24;2(6090):795–797. doi: 10.1136/bmj.2.6090.795. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gordon E. M., Johnson A. G., Williams G. Gastric assessment of prospective renal-transplant patients. Lancet. 1972 Jan 29;1(7744):226–229. doi: 10.1016/s0140-6736(72)90623-x. [DOI] [PubMed] [Google Scholar]
  8. Gray G. R., Smith I. S., McKenzie I., Crean G. P., Gillespie G. Oral cimetidine in severe duodenal ulceration. A double-blind controlled trial. Lancet. 1977 Jan 1;1(8001):4–7. doi: 10.1016/s0140-6736(77)91650-6. [DOI] [PubMed] [Google Scholar]
  9. Grimson T. A. Reactions to cimetidine. Lancet. 1977 Apr 16;1(8016):858–858. doi: 10.1016/s0140-6736(77)92808-2. [DOI] [PubMed] [Google Scholar]
  10. Johnson L. R. Source of the histamine released during damage to the gastric mucosa by acetic acid. Gastroenterology. 1968 Jan;54(1):8–15. [PubMed] [Google Scholar]
  11. Kaplan E. L., Hill B. J., Canterbury J. M., Reiss E., Peskin G. W. Calcium-induced gastric hypersecretion: lack of effect of endogenous parathyroid hormone. J Surg Res. 1972 Apr;12(4):229–233. doi: 10.1016/0022-4804(72)90016-9. [DOI] [PubMed] [Google Scholar]
  12. Katz A. I., Hampers C. L., Merrill J. P. Secondary hyperparathyroidism and renal osteodystrophy in chronic renal failure. Analysis of 195 patients, with observations on the effects of chronic dialysis, kidney transplantation and subtotal parathyroidectomy. Medicine (Baltimore) 1969 Sep;48(5):333–374. [PubMed] [Google Scholar]
  13. Korman M. G., Laver M. C., Hansky J. Hypergastrinaemia in chronic renal failure. Br Med J. 1972 Jan 22;1(5794):209–210. doi: 10.1136/bmj.1.5794.209. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Langman M. J., Cooke A. R. Gastric and duodenal ulcer and their associated diseases. Lancet. 1976 Mar 27;1(7961):680–683. doi: 10.1016/s0140-6736(76)92790-2. [DOI] [PubMed] [Google Scholar]
  15. Macdougall B. R., Bailey R. J., Williams R. H2-receptor antagonists and antacids in the prevention of acute gastrointestinal haemorrhage in fulminant hepatic failure. Two controlled trials. Lancet. 1977 Mar 19;1(8012):617–619. doi: 10.1016/s0140-6736(77)92055-4. [DOI] [PubMed] [Google Scholar]
  16. Moody F. G., Cheung L. Y., Simons M. A., Zalewsky C. Stress and the acute gastric mucosal lesion. Am J Dig Dis. 1976 Feb;21(2):148–154. doi: 10.1007/BF01072062. [DOI] [PubMed] [Google Scholar]
  17. Moore T. C., Thompson D. P., Glassock R. J. Elevation in urinary and blood histamine following clinical renal transplantation. Ann Surg. 1971 Mar;173(3):381–388. doi: 10.1097/00000658-197103000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Shepherd A. M., Stewart W. K., Wormsley K. G. Peptic ulceration in chronic renal failure. Lancet. 1973 Jun 16;1(7816):1357–1359. doi: 10.1016/s0140-6736(73)91677-2. [DOI] [PubMed] [Google Scholar]
  19. Van Cutsem J. M., Thienpont D. Miconazole, a broad-spectrum antimycotic agent with antibacterial activity. Chemotherapy. 1972;17(6):392–404. doi: 10.1159/000220875. [DOI] [PubMed] [Google Scholar]
  20. Vandevelde A. G., Mauceri A. A., Johnson J. E., 3rd 5-fluorocytosine in the treatment of mycotic infections. Ann Intern Med. 1972 Jul;77(1):43–51. doi: 10.7326/0003-4819-77-1-43. [DOI] [PubMed] [Google Scholar]
  21. Wiener S. N., Vertes V., Shapiro H. The upper gastrointestinal tract in patients ungergoing chronic dialysis. Radiology. 1969 Jan;92(1):110–114. doi: 10.1148/92.1.110. [DOI] [PubMed] [Google Scholar]
  22. Yalow R. S., Berson S. A. Radioimmunoassay of gastrin. Gastroenterology. 1970 Jan;58(1):1–14. [PubMed] [Google Scholar]

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