Abstract
Sections of breast carcinomas removed from 69 patients six to 13 years previously were examined using an immunoperoxidase technique to determine whether carcinoembryonic antigen (CEA) was present. Patients who had CEA-negative tumours had significantly higher five- and 10-year survival rates. The difference was not related to the stage of the disease, postoperative treatment, or histological type of tumour. These results suggest that immunohistological assessment of CEA in breast-cancer tissue may provide more precise prognostic information.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bivins B. A., Meeker W. R., Jr, Griffen W. O., Jr, Pellegrini J., Parker J. C., Jr Carcinoembryonic antigen (CEA) levels and tumor histology in colon cancer. J Surg Res. 1975 Mar;18(3):257–261. doi: 10.1016/0022-4804(75)90149-3. [DOI] [PubMed] [Google Scholar]
- DeLellis R. A., Rule A. H., Spiler I., Nathanson L., Tashjian A. H., Jr, Wolfe H. J. Calcitonin and carcinoembryonic antigen as tumor markers in medullary thyroid carcinoma. Am J Clin Pathol. 1978 Oct;70(4):587–594. doi: 10.1093/ajcp/70.4.587. [DOI] [PubMed] [Google Scholar]
- DeLellis R. A., Wolfe H. J., Rule A. H. Carcinoembryonic antigen as a tissue marker in medullary thyroid carcinoma. N Engl J Med. 1978 Nov 9;299(19):1082–1082. doi: 10.1056/NEJM197811092991926. [DOI] [PubMed] [Google Scholar]
- Horne C. H., Reid I. N., Milne G. D. Prognostic significance of inappropriate production of pregnancy proteins by breast cancers. Lancet. 1976 Aug 7;2(7980):279–282. doi: 10.1016/s0140-6736(76)90731-5. [DOI] [PubMed] [Google Scholar]
- Shousha S., Lyssiotis T. Correlation of carcinoembryonic antigen in tissue sections with spread of mammary carcinoma. Histopathology. 1978 Nov;2(6):433–447. doi: 10.1111/j.1365-2559.1978.tb01737.x. [DOI] [PubMed] [Google Scholar]
- Taylor C. R. Immunoperoxidase techniques: practical and theoretical aspects. Arch Pathol Lab Med. 1978 Mar;102(3):113–121. [PubMed] [Google Scholar]
- Wanebo H. J., Rao B., Pinsky C. M., Hoffman R. G., Stearns M., Schwartz M. K., Oettgen H. F. Preoperative carcinoembryonic antigen level as a prognostic indicator in colorectal cancer. N Engl J Med. 1978 Aug 31;299(9):448–451. doi: 10.1056/NEJM197808312990904. [DOI] [PubMed] [Google Scholar]