Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1979 Apr 7;1(6168):928–930. doi: 10.1136/bmj.1.6168.928

High-density lipoprotein in chronic renal failure and after renal transplantation.

E Savdie, J C Gibson, J H Stewart, L A Simons
PMCID: PMC1598619  PMID: 219935

Abstract

Serum high-density-lipoprotein (HDL) cholesterol and apoprotein (apo) A concentrations were significantly reduced at the time of renal transplantation in 26 patients with chronic renal failure. In a prospective evaluation the behaviour of HDL concentrations after grafting was found to depend on renal function. Graft function was sustained in 19 patients, in whom HDL-cholesterol and apo A concentrations increased to lie within normal limits by six months after the operation. Successful transplantation also restored to normal the lipid and protein content of HDL as expressed by the ratio of HDL cholesterol to apo A. When transplant function was not sustained (seven patients), however, no changes in HDL were observed up to the time of the graft loss. Such changes in HDL with successful kidney grafting augur well in a population with many risk factors for coronary heart disease.

Full text

PDF
928

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abbott L. K., Elliot C., Aitken J. M., Somer J. B. Serum lipoprotein abnormalities in renal allograft recipients. Atherosclerosis. 1978 Jun;30(2):97–107. doi: 10.1016/0021-9150(78)90053-9. [DOI] [PubMed] [Google Scholar]
  2. Allain C. C., Poon L. S., Chan C. S., Richmond W., Fu P. C. Enzymatic determination of total serum cholesterol. Clin Chem. 1974 Apr;20(4):470–475. [PubMed] [Google Scholar]
  3. Anderson D. W. H.D.L. cholesterol: the variable components. Lancet. 1978 Apr 15;1(8068):819–820. doi: 10.1016/s0140-6736(78)93014-3. [DOI] [PubMed] [Google Scholar]
  4. Bagdade J. D., Albers J. J. Plasma high-density lipoprotein concentrations in chronic-hemodialysis and renal-transplant patients. N Engl J Med. 1977 Jun 23;296(25):1436–1439. doi: 10.1056/NEJM197706232962504. [DOI] [PubMed] [Google Scholar]
  5. Belfrage P., Berg B., Hägerstrand I., Nilsson-Ehle P., Tornqvist H., Wiebe T. Alterations of lipid metabolism in healthy volunteers during long-term ethanol intake. Eur J Clin Invest. 1977 Apr;7(2):127–131. doi: 10.1111/j.1365-2362.1977.tb01584.x. [DOI] [PubMed] [Google Scholar]
  6. Brunzell J. D., Albers J. J., Haas L. B., Goldberg A. P., Agadoa L., Sherrard D. J. Prevalence of serum lipid abnormalities in chronic hemodialysis. Metabolism. 1977 Aug;26(8):903–910. doi: 10.1016/0026-0495(77)90009-9. [DOI] [PubMed] [Google Scholar]
  7. Cattran D. C., Fenton S. S., Wilson D. R., Steiner G. Defective triglyceride removal in lipemia associated with peritoneal dialysis and haemodialysis. Ann Intern Med. 1976 Jul;85(1):29–33. doi: 10.7326/0003-4819-85-1-29. [DOI] [PubMed] [Google Scholar]
  8. Ewing A. M., Freeman N. K., Lindgren F. T. The analysis of human serum lipoprotein distributions. Adv Lipid Res. 1965;3:25–61. [PubMed] [Google Scholar]
  9. Gordon T., Castelli W. P., Hjortland M. C., Kannel W. B., Dawber T. R. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med. 1977 May;62(5):707–714. doi: 10.1016/0002-9343(77)90874-9. [DOI] [PubMed] [Google Scholar]
  10. Ibels L. S., Simons L. A., King J. O., Williams P. F., Neale F. C., Stewart J. H. Studies on the nature and causes of hyperlipidaemia in uraemia, maintenance dialysis and renal transplantation. Q J Med. 1975 Oct;44(176):601–614. [PubMed] [Google Scholar]
  11. Ibels L. S., Stewart J. H., Mahony J. F., Neale F. C., Sheil A. G. Occlusive arterial disease in uraemic and haemodialysis patients and renal transplant recipients. A study of the incidence of arterial disease and of the prevalence of risk factors implicated in the pathogenesis of arteriosclerosis. Q J Med. 1977 Apr;46(182):197–214. [PubMed] [Google Scholar]
  12. Ibels L. S., Stewart J. H., Mahony J. F., Sheil A. G. Deaths from occlusive arterial disease in renal allograft recipients. Br Med J. 1974 Aug 31;3(5930):552–554. doi: 10.1136/bmj.3.5930.552. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ibels S. L., Reardon M. F., Nestel P. J. Plasma post-heparin lipolytic activity and triglyceride clearance in uremic and hemodialysis patients and renal allograft recipients. J Lab Clin Med. 1976 Apr;87(4):648–658. [PubMed] [Google Scholar]
  14. KANNEL W. B., DAWBER T. R., KAGAN A., REVOTSKIE N., STOKES J., 3rd Factors of risk in the development of coronary heart disease--six year follow-up experience. The Framingham Study. Ann Intern Med. 1961 Jul;55:33–50. doi: 10.7326/0003-4819-55-1-33. [DOI] [PubMed] [Google Scholar]
  15. Kostner G. M. Letter: Enzymatic determination of cholesterol in high-density lipoprotein fractions prepared by polyanion precipitation. Clin Chem. 1976 May;22(5):695–695. [PubMed] [Google Scholar]
  16. Lewis L. A., Zuehlke V., Nakamoto S., Kolff W. J., Page I. H. Renal regulation of serum alpha-lipoproteins. Decrease of alpha-lipoproteins in the absence of renal function. N Engl J Med. 1966 Nov 17;275(20):1097–1100. doi: 10.1056/NEJM196611172752004. [DOI] [PubMed] [Google Scholar]
  17. Lindner A., Charra B., Sherrard D. J., Scribner B. H. Accelerated atherosclerosis in prolonged maintenance hemodialysis. N Engl J Med. 1974 Mar 28;290(13):697–701. doi: 10.1056/NEJM197403282901301. [DOI] [PubMed] [Google Scholar]
  18. Mahony J. F., Ibels L. S., Sheil R., Storey B. G., Stewart J. H. Renal transplantation. Effect on the ischemic heart disease of essential malignant hypertension. JAMA. 1976 May 24;235(21):2318–2320. doi: 10.1001/jama.235.21.2318. [DOI] [PubMed] [Google Scholar]
  19. Miller N. E., Thelle D. S., Forde O. H., Mjos O. D. The Tromsø heart-study. High-density lipoprotein and coronary heart-disease: a prospective case-control study. Lancet. 1977 May 7;1(8019):965–968. doi: 10.1016/s0140-6736(77)92274-7. [DOI] [PubMed] [Google Scholar]
  20. Rhoads G. G., Gulbrandsen C. L., Kagan A. Serum lipoproteins and coronary heart disease in a population study of Hawaii Japanese men. N Engl J Med. 1976 Feb 5;294(6):293–298. doi: 10.1056/NEJM197602052940601. [DOI] [PubMed] [Google Scholar]
  21. Schaefer E. J., Levy R. I., Anderson D. W., Danner R. N., Brewer H. B., Jr, Blackwelder W. C. Plasma-triglycerides in regulation of H.D.L.-cholesterol levels. Lancet. 1978 Aug 19;2(8086):391–393. doi: 10.1016/s0140-6736(78)91863-9. [DOI] [PubMed] [Google Scholar]
  22. Sheil A. G., Kelly G. E., Mears D., May J., Johnson J. R., Ibels L. S., Stewart J. H. Antilymphocyte globulin in patients with renal allografts from cadaveric donors. Late results of a controlled trail. Lancet. 1973 Aug 4;2(7823):227–228. doi: 10.1016/s0140-6736(73)93132-2. [DOI] [PubMed] [Google Scholar]
  23. Spaulding S. W., Gregerman R. I. Free thyroxine in serum by equilibrium dialysis: effects of dilution, specific ions and inhibitors of binding. J Clin Endocrinol Metab. 1972 Jun;34(6):974–982. doi: 10.1210/jcem-34-6-974. [DOI] [PubMed] [Google Scholar]
  24. Wilson D. E., Lees R. S. Metabolic relationships among the plasma lipoproteins. Reciprocal changes in the concentrations of very low and low density lipoproteins in man. J Clin Invest. 1972 May;51(5):1051–1057. doi: 10.1172/JCI106896. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES