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. 1979 Jun 9;1(6177):1534–1536. doi: 10.1136/bmj.1.6177.1534

Variation in plasma prednisolone concentrations in renal transplant recipients given enteric-coated prednisolone.

R G Henderson, T Wheatley, J English, J Chakraborty, V Marks
PMCID: PMC1599654  PMID: 380747

Abstract

Renal transplant recipients receiving intermittent haemodialysis and kept under normal ward conditions showed appreciable differences in plasma prednisolone concentrations after therapeutic doses of enteric-coated prednisolone tablets. This gross day-to-day variation occurred irrespective of the dosage used. Breakfast given before prednisolone tended to reduce the rate of absorption of the drug, the effect being quantitatively most pronounced with large doses. Haemodialysis had no apparent effect on the elimination of prednisolone from plasma. Such erratic blood concentrations of prednisolone as observed in these patients, possibly resulting from variable absorption, may be potentially hazardous. Hence use of enteric-coated tablets in renal transplant recipients should be viewed with caution.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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