Skip to main content
NCBI home page
British Medical Journal logoLink to British Medical Journal
. 1979 Jun 9;1(6177):1536–1538. doi: 10.1136/bmj.1.6177.1536

Raised blood pressure and plasma noradrenaline concentrations in teenagers and young adults selected from an open population.

A Hofman, F Boomsma, M A Schalekamp, H A Valkenburg
PMCID: PMC1599662  PMID: 466104

Abstract

Plasma noradrenaline (PNA) concentrations were measured in 38 subjects aged 13-23, who were followed up for two to four years after an initial blood-pressure (BP) reading of 140/90 mm Hg or over was obtained, and in 39 age-matched controls from the same open population. Subjects who were hypertensive when the PNA concentration was measured had a significantly higher concentration (351 +/- SE 26 pg/ml) compared with their controls (248 +/- 29 pg/ml). Furthermore, in those subjects in whom the mean arterial pressure decreased by under 5% during the follow-up period the mean concentration was 363 +/- 27 pg/ml, compared with 271 +/- 29 pg/ml in their controls. PNA concentrations and systolic BP were positively correlated. A positive association between PNA concentrations and age was observed in the controls but not the subjects with hypertension, owing to the higher concentrations in younger hypertensive subjects.

Full text

PDF
1536

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown J. J., Lever A. F., Robertson J. I. Pathogenesis of essential hypertension. Lancet. 1976 Jun 5;1(7971):1217–1219. doi: 10.1016/s0140-6736(76)92164-4. [DOI] [PubMed] [Google Scholar]
  2. Carruthers M., Conway N., Somerville W., Taggart P., Bates D. Validity of plasma-catecholamine estimations. Lancet. 1970 Jul 11;1(7663):62–67. doi: 10.1016/s0140-6736(70)92638-3. [DOI] [PubMed] [Google Scholar]
  3. Franco-Morselli R., Elghozi J. L., Joly E., Di Giuilio S., Meyer P. Increased plasma adrenaline concentrations in benign essential hypertension. Br Med J. 1977 Nov 12;2(6097):1251–1254. doi: 10.1136/bmj.2.6097.1251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Louis W. J., Doyle A. E., Anavekar S. Plasma norepinephrine levels in essential hyoertension. N Engl J Med. 1973 Mar 22;288(12):599–601. doi: 10.1056/NEJM197303222881203. [DOI] [PubMed] [Google Scholar]
  5. Miller R. A., Shekelle R. B. Blood pressure in tenth-grade students: results from the Chicago Heart Association Pediatric Heart Screening Project. Circulation. 1976 Dec;54(6):993–1000. doi: 10.1161/01.cir.54.6.993. [DOI] [PubMed] [Google Scholar]
  6. Miura Y., Kobayashi K., Sakuma H., Tomioka H., Adachi M., Yoshinaga K. Plasma norepinephrine levels and hemodynamics in young patients with essential hypertension. Jpn Circ J. 1978 May;42(5):609–612. doi: 10.1253/jcj.42.609. [DOI] [PubMed] [Google Scholar]
  7. Rames L. K., Clarke W. R., Connor W. E., Reiter M. A., Lauer R. M. Normal blood pressure and the evaluation of sustained blood pressure elevation in childhood: the Muscatine study. Pediatrics. 1978 Feb;61(2):245–251. [PubMed] [Google Scholar]
  8. Sauerbier I., von Mayersbach H. Circadian variation of catecholamines in human blood. Horm Metab Res. 1977 Nov;9(6):529–530. doi: 10.1055/s-0028-1095589. [DOI] [PubMed] [Google Scholar]
  9. Sever P. S., Osikowska B., Birch M., Tunbridge R. D. Plasma-noradrenaline in essential hypertension. Lancet. 1977 May 21;1(8021):1078–1081. doi: 10.1016/s0140-6736(77)92335-2. [DOI] [PubMed] [Google Scholar]
  10. Wright B. M., Dore C. F. A random-zero sphygmomanometer. Lancet. 1970 Feb 14;1(7642):337–338. doi: 10.1016/s0140-6736(70)90709-9. [DOI] [PubMed] [Google Scholar]
  11. Zinner S. H., Martin L. F., Sacks F., Rosner B., Kass E. H. A longitudinal study of blood pressure in childhood. Am J Epidemiol. 1974 Dec;100(6):437–442. doi: 10.1093/oxfordjournals.aje.a112055. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES