Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1980 Jan 12;280(6207):80–81. doi: 10.1136/bmj.280.6207.80

Platelet-release reaction in myocardial infarction.

S Heptinstall, G P Mulley, P M Taylor, J R Mitchell
PMCID: PMC1600202  PMID: 7353131

Abstract

A study was made of the platelet-release reaction in heparinised platelet-rich plasma taken from 26 patients, of whom 22 had sustained a definite and four a possible myocardial infarction, and from 54 age-matched controls. No significant differences in reaction were observed between the two groups. Signficant differences were seen, however, between eight patients who died within a year after infarction and the controls (P less than 0.01) and the remaining 18 patients who survived (P = 0.02). These differences were abolished when sodium citrate was included in the experimental procedure. Poor prognosis was thus related to an increased platelet-release reaction after infarction.

Full text

PDF
80

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Davis J. W. Defective platelet disaggregation associated with occlusive arterial diseases. Angiology. 1973 Jul-Aug;24(7):391–397. doi: 10.1177/000331977302400703. [DOI] [PubMed] [Google Scholar]
  2. Dreyfuss F., Zahavi J. Adenosine diphosphate induced platelet aggregation in myocardial infarction and ischemic heart disease. Atherosclerosis. 1973 Jan-Feb;17(1):107–120. doi: 10.1016/0021-9150(73)90139-1. [DOI] [PubMed] [Google Scholar]
  3. Goldenfarb P. B., Cathey M. H., Zucker S., Wilber P., Corrigan J. J., Jr Changes in the hemostatic mechanism after myocardial infarction. Circulation. 1971 Apr;43(4):538–546. doi: 10.1161/01.cir.43.4.538. [DOI] [PubMed] [Google Scholar]
  4. Harrison M. J., Emmons P. R., Mitchell J. R. The variability of human platelet aggregation. J Atheroscler Res. 1967 Mar-Apr;7(2):197–205. doi: 10.1016/s0368-1319(67)80081-4. [DOI] [PubMed] [Google Scholar]
  5. Heptinstall S., Mulley G. P. Adenosine diphosphate induced platelet aggregation and release reaction in heparinized platelet rich plasma and the influence of added citrate. Br J Haematol. 1977 Aug;36(4):565–571. doi: 10.1111/j.1365-2141.1977.tb00997.x. [DOI] [PubMed] [Google Scholar]
  6. Macfarlane D. E., Walsh P. N., Mills D. C., Holmsen H., Day H. J. The role of thrombin in ADP-induced platelet aggregation and release: a critical evaluation. Br J Haematol. 1975 Aug;30(4):457–463. doi: 10.1111/j.1365-2141.1975.tb01860.x. [DOI] [PubMed] [Google Scholar]
  7. Mustard J. F., Perry D. W., Kinlough-Rathbone R. L., Packham M. A. Factors responsible for ADP-induced release reaction of human platelets. Am J Physiol. 1975 Jun;228(6):1757–1765. doi: 10.1152/ajplegacy.1975.228.6.1757. [DOI] [PubMed] [Google Scholar]
  8. O'Brien J. R., Heywood J. B., Heady J. A. The quantitation of platelet aggregation induced by four compounds: a study in relation to myocardial infarction. Thromb Diath Haemorrh. 1966 Dec 1;16(3):752–767. [PubMed] [Google Scholar]
  9. Rees B. W. Technique for the estimation of abnormal disaggregation patterns in platelets. Med Lab Technol. 1975 Apr;32(2):99–104. [PubMed] [Google Scholar]
  10. Salky N., Dugdale M. Platelet abnormalities in ischemic heart disease. Am J Cardiol. 1973 Oct;32(5):612–617. doi: 10.1016/s0002-9149(73)80053-0. [DOI] [PubMed] [Google Scholar]
  11. Sano T., Boxer M. G., Boxer L. A., Yokoyama M. Platelet sensitivity to aggregation in normal and diseased groups. A method for assessment of platelet aggregability. Thromb Diath Haemorrh. 1971 Jun 30;25(3):524–531. [PubMed] [Google Scholar]
  12. Szczeklik A., Gryglewski R. J., Musiał J., Grodzińska L., Serwońska M., Marcinkiewicz E. Thromboxane generation and platelet aggregation in survivals of myocardial infarction. Thromb Haemost. 1978 Aug 31;40(1):66–74. [PubMed] [Google Scholar]
  13. White A. M., Heptinstall S. Contribution of platelets to thrombus formation. Br Med Bull. 1978 May;34(2):123–128. doi: 10.1093/oxfordjournals.bmb.a071481. [DOI] [PubMed] [Google Scholar]
  14. Wu K. K., Hoak J. C. Spontaneous platelet aggregation in arterial insufficiency: mechanisms and implications. Thromb Haemost. 1976 Jun 30;35(3):702–711. [PubMed] [Google Scholar]
  15. Zahavi J., Dreyfuss F. An abnormal pattern of adenosine diphosphate-induced platelet aggregation in acute myocardial infarction. Thromb Diath Haemorrh. 1969 Feb 28;21(1):76–88. [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES