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. 1980 Mar 15;280(6216):758–759. doi: 10.1136/bmj.280.6216.758

Ectopic production of methionine enkephalin and beta-endorphin.

P T Pullan, V Clement-Jones, R Corder, P J Lowry, G M Rees, L H Rees, G M Besser, M M Macedo, A Galvao-Teles
PMCID: PMC1600608  PMID: 7370641

Abstract

Immunoreactive methionine enkephalin and beta-endorphin were sought by serial dilution of tissue extracts and assay of chromatographic fractions in non-endocrine tumour tissue from three patients with the ectopic adrenocorticotrophin syndrome associated with carcinoid tumours and in normal lung tissue and thymic tissue from a patient with myasthenia gravis. In all cases serial dilution of extracts showed parellelism to standard radioimmunoassay curves. The two peptides were found in high concentration in the three tumours but were undetectable in the control tissues. In a single case tested the methionine enkephalin concentration in a vein draining the tumour was twice that in a peripheral vein. In view of their profound effect on behaviour in animals and potent analgesic activity in animals and man the ectopic secretion of methionine enkephalin and beta-endorphin may modify the clinical features of a wide variety of tumours and produce some of the diverse clinical syndromes associated with malignancy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Belluzzi J. D., Grant N., Garsky V., Sarantakis D., Wise C. D., Stein L. Analgesia induced in vivo by central administration of enkephalin in rat. Nature. 1976 Apr 15;260(5552):625–626. doi: 10.1038/260625a0. [DOI] [PubMed] [Google Scholar]
  2. Bloom F., Segal D., Ling N., Guillemin R. Endorphins: profound behavioral effects in rats suggest new etiological factors in mental illness. Science. 1976 Nov 5;194(4265):630–632. doi: 10.1126/science.185694. [DOI] [PubMed] [Google Scholar]
  3. Bloomfield G. A., Holdaway I. M., Corrin B., Ratcliffe J. G., Rees G. M., Ellison M., Rees L. H. Lung tumours and ACTH production. Clin Endocrinol (Oxf) 1977 Feb;6(2):95–104. doi: 10.1111/j.1365-2265.1977.tb02000.x. [DOI] [PubMed] [Google Scholar]
  4. Clement-Jones V., Lowry P. J., Rees L. H., Besser G. M. Met-enkephalin circulates in human plasma. Nature. 1980 Jan 17;283(5744):295–297. doi: 10.1038/283295a0. [DOI] [PubMed] [Google Scholar]
  5. Fras I., Litin E. M., Pearson J. S. Comparison of psychiatric symptoms in carcinoma of the pancreas with those in some other intra-abdominal neoplasms. Am J Psychiatry. 1967 Jun;123(12):1553–1562. doi: 10.1176/ajp.123.12.1553. [DOI] [PubMed] [Google Scholar]
  6. Gilkes J. J., Rees L. H., Besser G. M. Plasma immunoreactive corticotrophin and lipotrophin in Cushing's syndrome and Addison's disease. Br Med J. 1977 Apr 16;1(6067):996–998. doi: 10.1136/bmj.1.6067.996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Goldstein A. Opioid peptides endorphins in pituitary and brain. Science. 1976 Sep 17;193(4258):1081–1086. doi: 10.1126/science.959823. [DOI] [PubMed] [Google Scholar]
  8. Jacquet Y. F., Marks N. The C-fragment of beta-lipotropin: an endogenous neuroleptic or antipsychotogen? Science. 1976 Nov 5;194(4265):632–635. doi: 10.1126/science.185695. [DOI] [PubMed] [Google Scholar]
  9. Jeffcoate W. J., Rees L. H., McLoughlin L., Ratter S. J., Hope J., Lowry P. J., Besser G. M. beta-Endorphin in human cerebrospinal fluid. Lancet. 1978 Jul 15;2(8081):119–121. doi: 10.1016/s0140-6736(78)91506-4. [DOI] [PubMed] [Google Scholar]
  10. Kerr T. A., Schapira K., Roth M. he relationship between premature death and affective disorders. Br J Psychiatry. 1969 Nov;115(528):1277–1282. doi: 10.1192/bjp.115.528.1277. [DOI] [PubMed] [Google Scholar]
  11. Loh H. H., Tseng L. F., Wei E., Li C. H. beta-endorphin is a potent analgesic agent. Proc Natl Acad Sci U S A. 1976 Aug;73(8):2895–2898. doi: 10.1073/pnas.73.8.2895. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Mains R. E., Eipper B. A., Ling N. Common precursor to corticotropins and endorphins. Proc Natl Acad Sci U S A. 1977 Jul;74(7):3014–3018. doi: 10.1073/pnas.74.7.3014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Orth D. N., Guillemin R., Ling N., Nicholson W. E. Immunoreactive endorphins, lipotropins and corticotropins in a human nonpituitary tumor: evidence for a common precursor. J Clin Endocrinol Metab. 1978 May;46(5):849–852. doi: 10.1210/jcem-46-5-849. [DOI] [PubMed] [Google Scholar]
  14. Sullivan S. N., Bloom S. R., Polak J. M. Enkephalin in peripheral neuroendocrine tumours. Lancet. 1978 May 6;1(8071):986–987. doi: 10.1016/s0140-6736(78)90271-4. [DOI] [PubMed] [Google Scholar]

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