Abstract
A double-blind placebo-controlled trial of 100, 400, and 800 micrograms inhaled salbutamol powder was conducted on 12 children. The protective effect at 10 minutes, two hours, and four hours was assessed by histamine challenge. At 10 minutes there was good protection with all doses, but by four hours there was significant protection only with 800 micrograms (p less than 0.01). Salbutamol powder may need to be taken at least every four hours for complete protection. There was a dose-related effect with a single dose of up to 800 micrograms; increasing the dose increased the effect and duration of action. Currently advertised dose regimens of salbutamol powder for children (200 micrograms three or four times a day) are apparently submaximal. Histamine challenge is a satisfactory method of assessing the proective effect of a drug in asthmatic children.
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- Chai H., Farr R. S., Froehlich L. A., Mathison D. A., McLean J. A., Rosenthal R. R., Sheffer A. L., Spector S. L., Townley R. G. Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol. 1975 Oct;56(4):323–327. doi: 10.1016/0091-6749(75)90107-4. [DOI] [PubMed] [Google Scholar]
- Cockcroft D. W., Killian D. N., Mellon J. J., Hargreave F. E. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy. 1977 May;7(3):235–243. doi: 10.1111/j.1365-2222.1977.tb01448.x. [DOI] [PubMed] [Google Scholar]
- Cockcroft D. W., Killian D. N., Mellon J. J., Hargreave F. E. Protective effect of drugs on histamine-induced asthma. Thorax. 1977 Aug;32(4):429–437. doi: 10.1136/thx.32.4.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cogswell J. J., Hull D., Milner A. D., Norman A. P., Taylor B. Lung function in childhood. I. The forced expiratory volumes in healthy children using a spirometer and reverse plethysmograph. Br J Dis Chest. 1975 Jan;69(1):40–50. doi: 10.1016/0007-0971(75)90054-6. [DOI] [PubMed] [Google Scholar]
- Hambleton G., Shinebourne E. A. Evaluation of the effects of isoprenaline and salbutamol aerosols on airways obstruction and pulse rates of children with asthma. Arch Dis Child. 1970 Dec;45(244):766–768. doi: 10.1136/adc.45.244.766. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hetzel M. R., Clark T. J. Comparison of salbutamol Rotahaler with conventional pressurized aerosol. Clin Allergy. 1977 Nov;7(6):563–568. doi: 10.1111/j.1365-2222.1977.tb01486.x. [DOI] [PubMed] [Google Scholar]
- Itkin I. H. Bronchial hypersensitivity to mecholyl and histamine in asthma subjects. J Allergy. 1967 Oct;40(4):245–256. doi: 10.1016/0021-8707(67)90087-1. [DOI] [PubMed] [Google Scholar]
- Lenney W., Milner A. D., Hiller E. J. Use of salbutamol powder in childhood asthma. Arch Dis Child. 1978 Dec;53(12):958–961. doi: 10.1136/adc.53.12.958. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mcnicol K. N., Macnicol K. N., Williams H. B. Spectrum of asthma in children. I. Clinical and physiological components. Br Med J. 1973 Oct 6;4(5883):7–11. doi: 10.1136/bmj.4.5883.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mellis C. M., Levison H. Bronchial reactivity in cystic fibrosis. Pediatrics. 1978 Mar;61(3):446–450. [PubMed] [Google Scholar]
- SAUNDERS K. B. MISUSE OF INHALED BRONCHODILATOR AGENTS. Br Med J. 1965 Apr 17;1(5441):1037–1038. doi: 10.1136/bmj.1.5441.1037. [DOI] [PMC free article] [PubMed] [Google Scholar]
- de VRIES, GOEI J. T., BOOY-NOORD H., ORIE N. G. Changes during 24 hours in the lung function and histamine hyperreactivity of the bronchial tree in asthmatic and bronchitic patients. Int Arch Allergy Appl Immunol. 1962;20:93–101. doi: 10.1159/000229248. [DOI] [PubMed] [Google Scholar]