Abstract
Changes in mood, plasma progesterone concentration, urinary volume, sodium excretion, sodium:potassium ratio, and body weight during the menstrual cycle were determined in 18 women with premenstrual syndrome and 10 symptomless (control group) women. Plasma progesterone concentration was higher in the women with symptoms during the postovulatory phase of the cycle, and the peak progesterone concentration appeared earlier. The changes in progesterone concentration were accompanied by a natriuresis and diuresis that fell towards preovulatory values in the premenstrual phase. Sodium retention was not confined to any definite period. Mood symptoms occurred after the changes in progesterone and electrolyte concentrations. Progesterone deficiency is probably not the cause of premenstrual syndrome. Thus treatment with progesterone is probably illogical unless a deficiency is detected. Treatment should be aimed at preventing the natriuretic effect of progesterone in the postovulatory phase and the sodium-retaining and water-retaining effects of aldosterone in the premenstrual phase.
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Selected References
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- Bäckström T., Mattsson B. Correlation of symptoms in pre-menstrual tension to oestrogen and progesterone concentrations in blood plasma. A preliminary study. Neuropsychobiology. 1975;1(2):80–86. doi: 10.1159/000117480. [DOI] [PubMed] [Google Scholar]
- Furuyama S., Nugent C. A. A radioimmunoassay for plasma progesterone. Steroids. 1971 Jun;17(6):663–674. doi: 10.1016/0039-128x(71)90082-1. [DOI] [PubMed] [Google Scholar]
- Ghose K., Coppen A. Bromocriptine and premenstrual syndrome: controlled study. Br Med J. 1977 Jan 15;1(6054):147–148. doi: 10.1136/bmj.1.6054.147-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LANDAU R. L., LUGIBIHL K. Inhibition of the sodium-retaining influence of aldosterone by progesterone. J Clin Endocrinol Metab. 1958 Nov;18(11):1237–1245. doi: 10.1210/jcem-18-11-1237. [DOI] [PubMed] [Google Scholar]
- O'Brien P. M., Craven D., Selby C., Symonds E. M. Treatment of premenstrual syndrome by spironolactone. Br J Obstet Gynaecol. 1979 Feb;86(2):142–147. doi: 10.1111/j.1471-0528.1979.tb10582.x. [DOI] [PubMed] [Google Scholar]
- Sampson G. A. Premenstrual syndrome: a double-blind controlled trial of progesterone and placebo. Br J Psychiatry. 1979 Sep;135:209–215. doi: 10.1192/bjp.135.3.209. [DOI] [PubMed] [Google Scholar]
- Smith S. L. The menstrual cycle and mood disturbances. Clin Obstet Gynecol. 1976 Jun;19(2):391–397. doi: 10.1097/00003081-197606000-00012. [DOI] [PubMed] [Google Scholar]
- Tonks C. M. Premenstrual tension. Br J Psychiatry. 1975;Spec No 9:399–408. [PubMed] [Google Scholar]