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. 1980 Jun 14;280(6229):1403–1406. doi: 10.1136/bmj.280.6229.1403

Alcohol consumption and premature death in middle-aged men.

B Peterson, H Kristenson, N H Sternby, E Trell, G Fex, B Hood
PMCID: PMC1601737  PMID: 6107142

Abstract

All the men living in Malmö born in 1926-9 were invited for a screening examination which included an assessment of alcohol consumption and measurement of gamma-glutamyltransferase (GGT) activity. They were followed for up to four years (median 2) and their mortality assessed. Sixty-two deaths occurred, 41 (0.9%) among the 4571 men who attended the screening investigation and 21 (1.3%) among the 1609 who did not respond to the invitation. Evidence of alcohol abuse or an alcohol-related cause of death was present in 25 (61%) of the deaths among the attenders and 13 (62%) of those among the non-responders. GGT values at the screening investigation were significantly increased in 19 (46%) of those who died, but established risk factors, such as cholesterol and triglyceride concentrations and blood pressure, had little predictive value. Measurement of GGT provided an objective index of alcohol consumption, though the full clinical importance of a raised value needs further assessment. The finding that heavy alcohol consumption was the single most important factor associated with premature death in these middle-aged men has important implications for prevention.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bagrel A., d'Houtaud A., Gueguen R., Siest G. Relations between reported alcohol consumption and certain biological variables in an "unselected" population. Clin Chem. 1979 Jul;25(7):1242–1246. [PubMed] [Google Scholar]
  2. Beaglehole R., Foulkes M. A., Prior I. A., Eyles E. F. Cholesterol and mortality in New Zealand Maoris. Br Med J. 1980 Feb 2;280(6210):285–287. doi: 10.1136/bmj.280.6210.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dyer A. R., Stamler J., Paul O., Berkson D. M., Lepper M. H., McKean H., Shekelle R. B., Lindberg H. A., Garside D. Alcohol consumption, cardiovascular risk factors, and mortality in two Chicago epidemiologic studies. Circulation. 1977 Dec;56(6):1067–1074. doi: 10.1161/01.cir.56.6.1067. [DOI] [PubMed] [Google Scholar]
  4. Kondo H., Hashida M., Momotani H. Serum gamma-glutamyl transpeptidase as a diagnostic aid in the periodic health examination. Sangyo Igaku. 1976 Mar;18(2):95–101. doi: 10.1539/joh1959.18.95. [DOI] [PubMed] [Google Scholar]
  5. Kristenson H., Trell E., Fex G., Hood B. Serum gamma-glutamyltransferase: statistical distribution in a middle-aged male population and evaluation of alcohol habits in individuals with elevated levels. Prev Med. 1980 Jan;9(1):108–119. doi: 10.1016/0091-7435(80)90062-6. [DOI] [PubMed] [Google Scholar]
  6. Lieber C. S. A public health strategy against alcoholism and its complications. Am J Med. 1978 Nov;65(5):722–725. doi: 10.1016/0002-9343(78)90788-x. [DOI] [PubMed] [Google Scholar]
  7. Rollason J. G., Pincherle G., Robinson D. Serum gamma glutamyl transpeptidase in relation to alcohol consumption. Clin Chim Acta. 1972 Jun;39(1):75–80. doi: 10.1016/0009-8981(72)90301-4. [DOI] [PubMed] [Google Scholar]
  8. Rosalki S. B., Rau D. Serum -glutamyl transpeptidase activity in alcoholism. Clin Chim Acta. 1972 Jun;39(1):41–47. doi: 10.1016/0009-8981(72)90297-5. [DOI] [PubMed] [Google Scholar]
  9. Selzer M. L. The Michigan alcoholism screening test: the quest for a new diagnostic instrument. Am J Psychiatry. 1971 Jun;127(12):1653–1658. doi: 10.1176/ajp.127.12.1653. [DOI] [PubMed] [Google Scholar]
  10. Straus R. Alcohol abuse and physicians' responsibility. Arch Intern Med. 1977 Nov;137(11):1513–1514. [PubMed] [Google Scholar]
  11. Tibblin G. Alkohol som riskfaktor för sjukdom och död. Lakartidningen. 1974 May 15;71(20):2053–2055. [PubMed] [Google Scholar]
  12. Tibblin G., Wilhelmsen L., Werkö L. Risk factors for myocardial infarction and death due to ischemic heart disease and other causes. Am J Cardiol. 1975 Apr;35(4):514–522. doi: 10.1016/0002-9149(75)90834-6. [DOI] [PubMed] [Google Scholar]
  13. Whitehead T. P., Clarke C. A., Whitfield A. G. Biochemical and haematological markers of alcohol intake. Lancet. 1978 May 6;1(8071):978–981. doi: 10.1016/s0140-6736(78)90261-1. [DOI] [PubMed] [Google Scholar]
  14. Whitfield J. B., Hensley W. J., Bryden D., Gallagher H. Some laboratory correlates of drinking habits. Ann Clin Biochem. 1978 Nov;15(6):297–303. doi: 10.1177/000456327801500171. [DOI] [PubMed] [Google Scholar]
  15. Wu A., Slavin G., Levi A. J. Elevated serum gamma-glutamyl-transferase (transpeptidase) and histological liver damage in alcoholism. Am J Gastroenterol. 1976 Apr;65(4):318–323. [PubMed] [Google Scholar]

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