Skip to main content
NCBI home page
British Medical Journal logoLink to British Medical Journal
. 1980 Jun 7;280(6228):1340–1344. doi: 10.1136/bmj.280.6228.1340

Anabolic effect of human parathyroid hormone fragment on trabecular bone in involutional osteoporosis: a multicentre trial.

J Reeve, P J Meunier, J A Parsons, M Bernat, O L Bijvoet, P Courpron, C Edouard, L Klenerman, R M Neer, J C Renier, D Slovik, F J Vismans, J T Potts Jr
PMCID: PMC1601798  PMID: 6992932

Abstract

After baseline studies, 21 patients with osteoporosis were treated with human parathyroid hormone fragment (PTH 1-34) given as once-daily subcutaneous injections for 6-24 months. The dose used did not cause hypercalcaemia even in the first few hours after injection. Calcium and phosphate balances improved in some patients, but there was no significant improvement in the group values. There were, however, substantial increases in iliac trabecular bone volume: the mean increase, confirmed by repeat blind measurements, was 70% above mean baseline volume. The new bone was histologically normal. Those patients who had the largest increases in 47Ca-kinetic and histomorphometric indices of new bone formation showed the greatest increases in trabecular bone volume, suggesting that treatment with human parathyroid hormone fragment caused a dissociation between formation and resorption rates that was confined to trabecular bone. Since vertebrae are four-fifths composed of trabecular bone, this hormone fragment may prove useful in treating patients with the crush fracture syndrome.

Full text

PDF
1340

Images in this article

1342FIG 1
on p.1342

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alkaline earth metabolism in adult man. A report prepared by a task group of Committee 2 of the International Commission on Radiological Protection (ICRP Publication 20). Health Phys. 1973 Feb;24(2):125–221. [PubMed] [Google Scholar]
  2. Bell G. H., Dunbar O., Beck J. S., Gibb A. Variations in strength of vertebrae with age and their relation to osteoporosis. Calcif Tissue Res. 1967;1(1):75–86. doi: 10.1007/BF02008077. [DOI] [PubMed] [Google Scholar]
  3. Bilezikian J. P., Canfield R. E., Jacobs T. P., Polay J. S., D'Adamo A. P., Eisman J. A., DeLuca H. F. Response of 1alpha,25-dihydroxyvitamin D3 to hypocalcemia in human subjects. N Engl J Med. 1978 Aug 31;299(9):437–441. doi: 10.1056/NEJM197808312990902. [DOI] [PubMed] [Google Scholar]
  4. CAMERON J. R., SORENSON J. MEASUREMENT OF BONE MINERAL IN VIVO: AN IMPROVED METHOD. Science. 1963 Oct 11;142(3589):230–232. doi: 10.1126/science.142.3589.230. [DOI] [PubMed] [Google Scholar]
  5. Cohn S. H., Ellis K. J., Wallach S., Zanzi I., Atkins H. L., Aloia J. F. Absolute and relative deficit in total-skeletal calcium and radial bone mineral in osteoporosis. J Nucl Med. 1974 Jun;15(6):428–435. [PubMed] [Google Scholar]
  6. Frost H. M. Tetracycline-based histological analysis of bone remodeling. Calcif Tissue Res. 1969;3(3):211–237. doi: 10.1007/BF02058664. [DOI] [PubMed] [Google Scholar]
  7. Meunier P., Courpron P., Edouard C., Bernard J., Bringuier J., Vignon G. Physiological senile involution and pathological rarefaction of bone. Quantitative and comparative histological data. Clin Endocrinol Metab. 1973 Jul;2(2):239–256. doi: 10.1016/s0300-595x(73)80042-8. [DOI] [PubMed] [Google Scholar]
  8. Parsons J. A., Reit B., Robinson C. J. A chick bioassay for parathyroid hormone. Endocrinology. 1973 Feb;92(2):454–462. doi: 10.1210/endo-92-2-454. [DOI] [PubMed] [Google Scholar]
  9. Parsons J. A., Zanelli J. M., Gray D., Rafferty B., Stevenson R. W. Double isotope estimates of intestinal calcium absorption in rats: enhancement by parathyroid hormone and 1,25-dihydroxycholecalciferol. Calcif Tissue Res. 1977 May;22 (Suppl):127–132. doi: 10.1007/BF02064052. [DOI] [PubMed] [Google Scholar]
  10. Parsons V., Mitchell C. J., Reeve J., Hesp R. The use of sodium fluoride, vitamin D and calcium supplements in the treatment of patients with axial osteoporosis. Calcif Tissue Res. 1977 May;22 (Suppl):236–240. doi: 10.1007/BF02064071. [DOI] [PubMed] [Google Scholar]
  11. Reeve J., Hesp R., Williams D., Hulme P., Klenerman L., Zanelli J. M., Darby A. J., Tregear G. W., Parsons J. A. Anabolic effect of low doses of a fragment of human parathyroid hormone on the skeleton in postmenopausal osteoporosis. Lancet. 1976 May 15;1(7968):1035–1038. doi: 10.1016/s0140-6736(76)92216-9. [DOI] [PubMed] [Google Scholar]
  12. Reeve J., Hesp R., Wootton R. A new tracer method for the estimation of rates of bone formation and breakdown in man. Calcif Tissue Res. 1977 May;22 (Suppl):311–313. doi: 10.1007/BF02064086. [DOI] [PubMed] [Google Scholar]
  13. Reeve J., Tregear G. W., Parsons J. A. Priliminary trial of low doses of human parathyroid hormone 1-34 peptide in treatment of osteoporosis. Calcif Tissue Res. 1976 Aug;21 (Suppl):469–477. [PubMed] [Google Scholar]
  14. Reeve J., Wootton R., Hesp B. A new method for calculating the accretion rate of bone calcium and some observations on the suitability of strontium-85 as a tracer for bone calcium. Calcif Tissue Res. 1976 Apr 20;(2):121–135. doi: 10.1007/BF02546402. [DOI] [PubMed] [Google Scholar]
  15. Schenk R. K., Merz W. A., Müller J. A quantitative histological study on bone resorption in human cancellous bone. Acta Anat (Basel) 1969;74(1):44–53. doi: 10.1159/000143361. [DOI] [PubMed] [Google Scholar]
  16. West R. R., Reed G. W. The measurement of bone mineral in vivo by photon beam scanning. Br J Radiol. 1970 Dec;43(516):886–893. doi: 10.1259/0007-1285-43-516-886. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES