TABLE 2.
Clinical and laboratory findings in infants born to mothers immunized against HPA-9b (Maxa)
Case | Child | HPA-9b (Maxa) antibody present | Maxa type of infant | PLT nadir (×109/L) | Time (days) to reach PLT count of 100 × 109/L | Bleeding symptoms | ICH | Treatment | Outcome |
---|---|---|---|---|---|---|---|---|---|
1 | 1 | Yes | Positive | 5 | 18 | Extensive petechiae at 12 hr | Small ICH | Random PLT transfusions, Days 1, 6, and 13 | No neurologic sequelae |
2 | Yes | Positive | 6 | 10 | Extensive petechiae and purpura at birth | Major ICH | Maternal and random PLT transfusion, Days 1 and 6 | Permanent disability | |
2 | 1 | Yes | Positive | 20 | 5 | Moderate petechiae at birth | No | None | Recovery |
2 | No | Negative | 225 | None | No | None | Normal infant | ||
3 | 1 | Yes | Positive | 7 | 18 | Moderate petechiae at birth | Small ICH | PLT transfusion, Days 1 and 7 | No neurologic |
2 | No | Negative | 235 | None | No | None | |||
4 | 1 | Yes | Positive | 6 | 30 | Moderate petechiae at birth | No | IV gamma globulin at 3 and 4 weeks of age | Recovery |
2 | Yes | Positive | 237 | None | No | Prenatal IV gamma globulin (last 2 months) | Normal infant | ||
5 | 1 | Yes | Positive | 30 | 5 | Moderate petechiae at birth | No | Random PLT transfusion, Day 2 | Recovery |
2 | Yes | Positive | 231 | None | No | Prenatal IV gamma globulin (last 2 months) | Normal infant |