Abstract
Human leucocyte antigens (HLA) and mixed lymphocyte reactions (MLR) were studied in 38 women with severe pre-eclampsia and their husbands. Thirty-nine women with normal pregnancies and their husbands served as controls. Thirty-three of the control women were matched for age and parity with members of the study group. Infants were studied when possible. HLA compatibility was increased in the pre-eclamptic group compared with matched controls and with theoretical estimates for possible matings. The one-way MLR at delivery showed diminished response of maternal to paternal and cord cells in pre-eclamptic women. This reduced maternal reactivity in women with pre-eclampsia may have a role in the illness, and paternal/maternal histocompatibility may be a feature of the severe form.
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Selected References
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- Jenkins D. M., Need J., Kajah S. M. Deficienty of specific HLA antibodies in severe pregnancy pre-eclampsia/eclampsia. Clin Exp Immunol. 1977 Mar;27(3):485–486. [PMC free article] [PubMed] [Google Scholar]
- Need J. A. Pre-eclampsia in pregnancies by different fathers: immunological studies. Br Med J. 1975 Mar 8;1(5957):548–549. doi: 10.1136/bmj.1.5957.548. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Opelz G., Terasaki P. I. Effect of blood-group on relation between HLA match and outcome of cadaver kidney transplants. Lancet. 1977 Jan 29;1(8005):220–222. doi: 10.1016/s0140-6736(77)91016-9. [DOI] [PubMed] [Google Scholar]
- Scott J. R., Beer A. E., Stastny P. Immunogenetic factors in preeclampsia and eclampsia. Erythrocyte, histocompatibility, and Y-dependent antigens. JAMA. 1976 Jan 26;235(4):402–404. [PubMed] [Google Scholar]