Abstract
Relapsing polychondritis is rare and its cause is unknown. The tissues affected are those with a high glycosaminoglycan content, such as cartilage, the aorta, the sclera and cornea, and parts of the ear. Symptoms can usually be controlled with oral steroids, but when there is coexistent progressive crescentic glomerulonephritis quadruple chemotherapy may be used. Three cases of the clinical syndrome of relapsing polychondritis were studied in which rapidly progressive cresentic glomerulonephritis developed. In two the patients appeared to respond to aggressive treatment with immunosuppressive agents and anticoagulants. The multisystemic nature of the disease, the renal lesions, and the response to treatment all suggested that the condition might be related to periarteritis nodosa.
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Selected References
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- Dolan D. L., Lemmon G. B., Jr, Teitelbaum S. L. Relapsing polychondritis. Analytical literature review and studies on pathogenesis. Am J Med. 1966 Aug;41(2):285–299. doi: 10.1016/0002-9343(66)90023-4. [DOI] [PubMed] [Google Scholar]
- Howell S. B., Epstein W. V. Circulating immunoglobulin complexes in Wegener's granulomatosis. Am J Med. 1976 Feb;60(2):259–268. doi: 10.1016/0002-9343(76)90435-6. [DOI] [PubMed] [Google Scholar]
- Hughes R. A., Berry C. L., Seifert M., Lessof M. H. Relapsing polychondritis. Three cases with a clinico-pathological study and literature review. Q J Med. 1972 Jul;41(163):363–380. [PubMed] [Google Scholar]
- McAdam L. P., O'Hanlan M. A., Bluestone R., Pearson C. M. Relapsing polychondritis: prospective study of 23 patients and a review of the literature. Medicine (Baltimore) 1976 May;55(3):193–215. [PubMed] [Google Scholar]