Abstract
A trial of low-dose subcutaneous heparin to prevent thromboembolic complications after myocardial infarction was carried out in 78 patients. Of the 37 heparin-treated patients only two (5%) developed evidence of leg vein thrombosis, while 14 (34%) of the 41 controls did so, and five controls developed pulmonary emboli. Leg vein thrombosis developed in 12 (50%) of the 24 controls who did not smoke cigarettes but in only two (13%) of the 17 controls who were cigarette smokers. Non-smokers who have a myocardial infarction should be given low-dose heparin subcutaneously to prevent leg vein thrombosis and pulmonary embolism.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Doll R. Letter: Smoking and deep vein thrombosis. Br Med J. 1974 Aug 17;3(5928):466–466. doi: 10.1136/bmj.3.5928.466-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Handley A. J., Emerson P. A., Fleming P. R. Heparin in the prevention of deep vein thrombosis after myocardial infarction. Br Med J. 1972 May 20;2(5811):436–438. doi: 10.1136/bmj.2.5811.436. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Handley A. J. Low-dose heparin after myocardial infarction. Lancet. 1972 Sep 23;2(7778):623–624. doi: 10.1016/s0140-6736(72)93016-4. [DOI] [PubMed] [Google Scholar]
- Handley A. J., Teather D. Influence of smoking on deep vein thrombosis after myocardial infarction. Br Med J. 1974 Jul 27;3(5925):230–231. doi: 10.1136/bmj.3.5925.230. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kakkar V. V., Nicolaides A. N., Renney J. T., Friend J. R., Clarke M. B. 125-I-labelled fibrinogen test adapted for routine screening for deep-vein thrombosis. Lancet. 1970 Mar 14;1(7646):540–542. doi: 10.1016/s0140-6736(70)90769-5. [DOI] [PubMed] [Google Scholar]
- Marks P., Emerson P. A. Increased incidence of deep vein thrombosis after myocardial infarction in non-smokers. Br Med J. 1974 Jul 27;3(5925):232–234. doi: 10.1136/bmj.3.5925.232. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Maurer B. J., Wray R., Shillingford J. P. Frequency of venous thrombosis after myocardial infarction. Lancet. 1971 Dec 25;2(7739):1385–1387. doi: 10.1016/s0140-6736(71)90666-0. [DOI] [PubMed] [Google Scholar]
- Nicolaides A. N., Kakkar V. V., Renney J. T., Kidner P. H., Hutchison D. C., Clarke M. B. Myocardial infarction and deep-vein thrombosis. Br Med J. 1971 Feb 20;1(5746):432–434. doi: 10.1136/bmj.1.5746.432. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Steffensen K. A. Coronary occlusion treated with small doses of heparin. Acta Med Scand. 1969 Dec;186(6):519–521. doi: 10.1111/j.0954-6820.1969.tb01515.x. [DOI] [PubMed] [Google Scholar]