Abstract
Giving clofibrate 2 g daily to seven patients significantly increased the biliary cholesterol concentration while the proportion of bile acids fell. Five patients on established clofibrate treatment were given 750 mg of chenodeoxycholic acid (CDCA) daily for one month. Biliary lipid analysis after the CDCA treatment showed a significant fall in the proportion of cholesterol and a rise in that of bile acids. The serum lipid concentrations, which had already been reduced by diet and clofibrate, showed a further significant reduction after the introduction of CDCA. This study suggests that CDCA may be usefully combined with clofibrate to reverse the tendency towards cholesterol saturation of bile and enhance the effect of lowering serum lipid concentrations.
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Selected References
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- Admirand W. H., Small D. M. The physicochemical basis of cholesterol gallstone formation in man. J Clin Invest. 1968 May;47(5):1043–1052. doi: 10.1172/JCI105794. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bateson M. C., Ross P. E., Murison J., Bouchier I. A. Effect of prolonged feeding with chenodeoxycholic acid on bile in patients with and without gallstones. Gut. 1977 Aug;18(8):599–605. doi: 10.1136/gut.18.8.599. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bennion L. J., Grundy S. M. Effects of obesity and caloric intake on biliary lipid metabolism in man. J Clin Invest. 1975 Oct;56(4):996–1011. doi: 10.1172/JCI108180. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cooper J., Geizerova H., Oliver M. F. Letter: Clofibrate and gallstones. Lancet. 1975 May 10;1(7915):1083–1083. doi: 10.1016/s0140-6736(75)91845-0. [DOI] [PubMed] [Google Scholar]
- Einarsson K., Hellström K., Kallner M. The effect of clofibrate on the elimination of cholesterol as bile acids in patients with hyperlipoproteinaemia type II and IV. Eur J Clin Invest. 1973 Jul;3(4):345–351. doi: 10.1111/j.1365-2362.1973.tb00361.x. [DOI] [PubMed] [Google Scholar]
- Hegardt F. G., Dam H. The solubility of cholesterol in aqueous solutions of bile salts and lecithin. Z Ernahrungswiss. 1971 Apr;10(3):223–233. doi: 10.1007/BF02020933. [DOI] [PubMed] [Google Scholar]
- Holzbach R. T., Marsh M., Olszewski M., Holan K. Cholesterol solubility in bile. Evidence that supersaturated bile is frequent in healthy man. J Clin Invest. 1973 Jun;52(6):1467–1479. doi: 10.1172/JCI107321. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miettinen T. A. Cholesterol production in obesity. Circulation. 1971 Nov;44(5):842–850. doi: 10.1161/01.cir.44.5.842. [DOI] [PubMed] [Google Scholar]
- Mok H. Y., Bell G. D., Dowling R. H. Effect of different doses of chenodeoxycholic acid on bile-lipid composition and on frequency of side-effects in patients with gallstones. Lancet. 1974 Aug 3;2(7875):253–257. doi: 10.1016/s0140-6736(74)91415-9. [DOI] [PubMed] [Google Scholar]
- Pertsemlidis D., Panveliwalla D., Ahrens E. H., Jr Effects of clofibrate and of an estrogen-progestin combination on fasting biliary lipids and cholic acid kinetics in man. Gastroenterology. 1974 Apr;66(4):565–573. [PubMed] [Google Scholar]
- Thomas P. J., Hofmann A. F. Letter: A simple calculation of the lithogenic index of bile: expressing biliary lipid composition on rectangular coordinates. Gastroenterology. 1973 Oct;65(4):698–700. [PubMed] [Google Scholar]
- WATANABE N., GIMBEL N. S., JOHNSTON C. G. Effect of polyunsaturated and saturated fatty acids on the cholesterol holding capacity of human bile. Arch Surg. 1962 Jul;85:136–141. doi: 10.1001/archsurg.1962.01310010140019. [DOI] [PubMed] [Google Scholar]