Abstract
With an immunofluorescence technique using rabbit hepatocytes isolated by a non-enzymatic method an autoantibody directed against liver-cell-membrance was identified. Sera from 361 patients with various liver diseases and 274 patients with primary non-hepatic diseases-many associated with non-organ-specific auto-antibodies-were examined. The antibody (LMA) was found in 27 out of 72 patients with hepatitis-B-surgace antigen (HBsAg)-negative chronic active hepatitis and in 17 out of 28 patients with HBsAg-negative non-alcoholic cirrhosis. Only two patients had LMA and HBsAg, and both had chronic active hepatitis. One patient with extrhepatic disease was found to have LMA, and this patient had biochemical evidence of liver disease. Hence there is a close correlation between the presence of LMA and HBsAg-negative chronic inflammatory liver diseases and its detection may help in diagnosis.
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Selected References
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- Dietrichson O., Nielsen J. O., Elling P., Christoffersen P. The relevance of a serological classification of chronic hepatitis. Acta Pathol Microbiol Scand B Microbiol Immunol. 1973 Oct;81(5):519–524. doi: 10.1111/j.1699-0463.1973.tb02237.x. [DOI] [PubMed] [Google Scholar]
- Doniach D., Walker J. G. A unified concept of autoimmune hepatitis. Lancet. 1969 Apr 19;1(7599):813–815. doi: 10.1016/s0140-6736(69)92072-8. [DOI] [PubMed] [Google Scholar]
- Hopf U., Meyer zum Büschenfelde K. H., Arnold W. Detection of a liver-membrane autoantibody in HBsAg-negative chronic active hepatitis. N Engl J Med. 1976 Mar 11;294(11):578–582. doi: 10.1056/NEJM197603112941103. [DOI] [PubMed] [Google Scholar]
- Hopf U., Meyer zum Büschenfelde K. H., Dierich M. P. Demonstration of binding sites for IgG Fc and the third complement component (C3) on isolated hepatocytes. J Immunol. 1976 Aug;117(2):639–645. [PubMed] [Google Scholar]
- Lindberg J., Lindholm A., Lundin P., Iwarson S. Trigger factors and HL-A antigens in chronic active hepatitis. Br Med J. 1975 Oct 11;4(5988):77–79. doi: 10.1136/bmj.4.5988.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miller J., Smith M. G., Mitchell C. G., Reed W. D., Eddleston A. L., Williams R. Cell-mediated immunity to a human liver-specific antigen in patients with active chronic hepatitis and primary biliary cirrhosis. Lancet. 1972 Aug 12;2(7772):296–297. doi: 10.1016/s0140-6736(72)92904-2. [DOI] [PubMed] [Google Scholar]
- Vischer T. L. Australia antigen and autoantibodies in chronic hepatitis. Br Med J. 1970 Jun 20;2(5711):695–698. doi: 10.1136/bmj.2.5711.695. [DOI] [PMC free article] [PubMed] [Google Scholar]