Abstract
To define the type of dietary fibre of fibre analogue with the greatest potential use in diabetic treatment, groups of four to six volunteers underwent 50-g glucose tolerance tests (GTT) with and without the addition of either guar, pectin, gum tragacanth, methylcellulose, wheat bran, or cholestyramine equivalent to 12 g fibre. The addition of each substance significantly reduced blood glucose concentration at one or more points during the GTT and generally reduced serum insulin concentrations. The greatest flattening of the glucose response was seen with guar, but this effect was abolished when hydrolysed non-viscous guar was used. The reduction in the mean peak rise in blood glucose concentration for each substance correlated positively with its viscosity (r = 0.926; P less than 0.01), as did delay in mouth-to-caecum transit time (r = 0.885; P less than 0.02). Viscous types of dietary fibre are therefore most likely to be therapeutically useful in modifying postprandial hyperglycaemia.
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- Bond J. H., Jr, Levitt M. D., Prentiss R. Investigation of small bowel transit time in man utilizing pulmonary hydrogen (H2) measurements. J Lab Clin Med. 1975 Apr;85(4):546–555. [PubMed] [Google Scholar]
- Calloway D. H., Murphy E. L., Bauer D. Determination of lactose intolerance by breath analysis. Am J Dig Dis. 1969 Nov;14(11):811–815. doi: 10.1007/BF02235972. [DOI] [PubMed] [Google Scholar]
- Haber G. B., Heaton K. W., Murphy D., Burroughs L. F. Depletion and disruption of dietary fibre. Effects on satiety, plasma-glucose, and serum-insulin. Lancet. 1977 Oct 1;2(8040):679–682. doi: 10.1016/s0140-6736(77)90494-9. [DOI] [PubMed] [Google Scholar]
- Jenkins D. J., Wolever T. M., Hockaday T. D., Leeds A. R., Howarth R., Bacon S., Apling E. C., Dilawari J. Treatment of diabetes with guar gum. Reduction of urinary glucose loss in diabetics. Lancet. 1977 Oct 15;2(8042):779–780. doi: 10.1016/s0140-6736(77)90721-8. [DOI] [PubMed] [Google Scholar]
- KEYS A., GRANDE F., ANDERSON J. T. Fiber and pectin in the diet and serum cholesterol concentration in man. Proc Soc Exp Biol Med. 1961 Mar;106:555–558. doi: 10.3181/00379727-106-26401. [DOI] [PubMed] [Google Scholar]
- Kiehm T. G., Anderson J. W., Ward K. Beneficial effects of a high carbohydrate, high fiber diet on hyperglycemic diabetic men. Am J Clin Nutr. 1976 Aug;29(8):895–899. doi: 10.1093/ajcn/29.8.895. [DOI] [PubMed] [Google Scholar]
- MCCANCE R. A., PRIOR K. M., WIDDOWSON E. M. A radiological study of the rate of passage of brown and white bread through the digestive tract of man. Br J Nutr. 1953;7(1-2):98–104. doi: 10.1079/bjn19530013. [DOI] [PubMed] [Google Scholar]
- Metz G., Gassull M. A., Leeds A. R., Blendis L. M., Jenkins D. J. A simple method of measuring breath hydrogen in carbohydrate malabsorption by end-expiratory sampling. Clin Sci Mol Med. 1976 Mar;50(3):237–240. doi: 10.1042/cs0500237. [DOI] [PubMed] [Google Scholar]
- Soeldner J. S., Slone D. Critical variables in the radioimmunoassay of serum insulin using the double antibody technic. Diabetes. 1965 Dec;14(12):771–779. doi: 10.2337/diab.14.12.771. [DOI] [PubMed] [Google Scholar]