Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1978 May 27;1(6124):1382–1386. doi: 10.1136/bmj.1.6124.1382

Is 24,25-dihydroxycholecalciferol a calcium-regulating hormone in man?

J A Kanis, T Cundy, M Bartlett, R Smith, G Heynen, G T Warner, R G Russell
PMCID: PMC1604777  PMID: 647302

Abstract

Small doses (1-10 microgram daily) of 24,25-dihydroxycholecalciferol (24,25-(OH)2D3), a renal metabolite of vitamin D of uncertain function, increased intestinal absorption of calcium in normal people and in patients with various disorders or mineral metabolism, including anephric subjects. In five of six patients studied, calcium balance increased, but, unlike 1,25-dihydroxycholecalciferol, 24,25-(OH)2D3 did not increase plasma or urinary calcium concentrations. These results suggest that 24,25-(OH)2D3 may be an important regulator of skeletal metabolism in man with potential value as a therapeutic agent.

Full text

PDF
1382

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baxter L. A., Deluca H. F., Bonjour J. P., Fleisch H. A. Inhibition of vitamin D metabolism by ethane-1-hydroxyl-1, 1-diphosphonate. Arch Biochem Biophys. 1974 Oct;164(2):655–662. doi: 10.1016/0003-9861(74)90077-0. [DOI] [PubMed] [Google Scholar]
  2. Boris A., Hurley J. F., Trmal T. Relative activities of some metabolites and analogs of cholecalciferol in stimulation of tibia ash weight in chicks otherwise deprived of vitamin D. J Nutr. 1977 Feb;107(2):194–198. doi: 10.1093/jn/107.2.194. [DOI] [PubMed] [Google Scholar]
  3. Boyle I. T., Omdahl J. L., Gray R. W., DeLuca H. F. The biological activity and metabolism of 24,25-dihydroxyvitamin D 3 . J Biol Chem. 1973 Jun 25;248(12):4174–4180. [PubMed] [Google Scholar]
  4. Brumbaugh P. F., Haussler M. R. Specific binding of 1alpha,25-dihydroxycholecalciferol to nuclear components of chick intestine. J Biol Chem. 1975 Feb 25;250(4):1588–1594. [PubMed] [Google Scholar]
  5. Chen T. C., Castillo L., Korycka-Dahl M., DeLuca H. F. Role of vitamin D metabolites in phosphate transport of rat intestine. J Nutr. 1974 Aug;104(8):1056–1060. doi: 10.1093/jn/104.8.1056. [DOI] [PubMed] [Google Scholar]
  6. Coburn J. W., Hartenbower D. L., Brickman A. S. Advances in vitamin D metabolism as they pertain to chronic renal disease. Am J Clin Nutr. 1976 Nov;29(11):1283–1299. doi: 10.1093/ajcn/29.11.1283. [DOI] [PubMed] [Google Scholar]
  7. DeLuca H. F. Regulation of vitamin D metabolism in the kidney. Adv Exp Med Biol. 1977;81:195–209. doi: 10.1007/978-1-4613-4217-5_22. [DOI] [PubMed] [Google Scholar]
  8. DeLuca H. F., Schnoes H. K. Metabolism and mechanism of action of vitamin D. Annu Rev Biochem. 1976;45:631–666. doi: 10.1146/annurev.bi.45.070176.003215. [DOI] [PubMed] [Google Scholar]
  9. Dick M. Use of cuprous thiocyanate as a short-term continuous marker for faeces. Gut. 1969 May;10(5):408–412. doi: 10.1136/gut.10.5.408. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Eisman J. A., Hamstra A. J., Kream B. E., DeLuca H. F. A sensitive, precise, and convenient method for determination of 1,25-dihydroxyvitamin D in human plasma. Arch Biochem Biophys. 1976 Sep;176(1):235–243. doi: 10.1016/0003-9861(76)90161-2. [DOI] [PubMed] [Google Scholar]
  11. Holick M. F., Baxter L. A., Schraufrogel P. K., Tavela T. E., DeLuca H. F. Metabolism and biologica. J Biol Chem. 1976 Jan 25;251(2):397–402. [PubMed] [Google Scholar]
  12. Kanis J. A., Russell R. G. Rate of reversal of hypercalcaemia and hypercalciuria induced by vitamin D and its 1alpha-hydroxylated derivatives. Br Med J. 1977 Jan 8;1(6053):78–81. doi: 10.1136/bmj.1.6053.78. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mawer E. B., Backhouse J., Davies M., Hill L. F., Taylor C. M. Metabolic fate of administered 1,25-dihydroxycholecalciferol in controls and in patients with hypoparathyroidism. Lancet. 1976 Jun 5;1(7971):1203–1206. doi: 10.1016/s0140-6736(76)92157-7. [DOI] [PubMed] [Google Scholar]
  14. Mawer E. B., Backhouse J., Hill L. F., Lumb G. A., De Silva P., Taylor C. M., Stanbury S. W. Vitamin D metabolism and parathyroid function in man. Clin Sci Mol Med. 1975 May;48(5):349–365. doi: 10.1042/cs0480349. [DOI] [PubMed] [Google Scholar]
  15. Mawer E. B., Taylor C. M., Backhouse J., Lumb G. A., Stanbury S. W. Failure of formation of 1,25-dihydroxycholecalciferol in chronic renal insufficiency. Lancet. 1973 Mar 24;1(7804):626–628. doi: 10.1016/s0140-6736(73)92197-1. [DOI] [PubMed] [Google Scholar]
  16. Norman A. W., Friedlander E. J., Henry H. Interrelationships between the key elements of the vitamin D endocrine system: 25-OH-D3-1-hydroxylase, serum calcium and phosphorus levels, intestinal 1,25(OH)2D3, and intestinal calcium binding protein. Adv Exp Med Biol. 1977;81:211–231. doi: 10.1007/978-1-4613-4217-5_23. [DOI] [PubMed] [Google Scholar]
  17. Raisz L. G., Trummel C. L., Holick M. F., DeLuca H. F. 1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture. Science. 1972 Feb 18;175(4023):768–769. doi: 10.1126/science.175.4023.768. [DOI] [PubMed] [Google Scholar]
  18. Reynolds J. J., Holick M. F., DeLuca H. F. The effects of vitamin D analogues on bone resorption. Calcif Tissue Res. 1974;15(4):333–339. doi: 10.1007/BF02059069. [DOI] [PubMed] [Google Scholar]
  19. Tanaka Y., DeLuca H. F., Ikekawa N., Morisaki M., Koizumi N. Determination of stereochemical configuration of the 24-hydroxyl group of 24,25-dihydroxyvitamin D3 and its biological importance. Arch Biochem Biophys. 1975 Oct;170(2):620–626. doi: 10.1016/0003-9861(75)90157-5. [DOI] [PubMed] [Google Scholar]
  20. Tanaka Y., Frank H., DeLuca H. F., Koizumi N., Ikekawa N. Importance of the stereochemical position of the 24-hydroxyl to biological activity of 24-hydroxyvitamin D3. Biochemistry. 1975 Jul 29;14(15):3293–3296. doi: 10.1021/bi00686a001. [DOI] [PubMed] [Google Scholar]
  21. Taylor C. M., Hughes S. E., de Silva P. Competitive protein binding assay for 24,25-dihydroxycholecalciferol. Biochem Biophys Res Commun. 1976 Jun 21;70(4):1243–1249. doi: 10.1016/0006-291x(76)91035-4. [DOI] [PubMed] [Google Scholar]
  22. Warner G. T., Oliver R. A whole-body counter for clinical measurements utilizing the 'shadow shield' technique. Phys Med Biol. 1966 Jan;11(1):83–94. doi: 10.1088/0031-9155/11/1/307. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES