Abstract
The effects of intravenous salbutamol (4 mug/kg) were compared with those of aerosol salbutamol (200 mug) in 10 asthmatic patients in a double-blind placebo-controlled study. Both methods of administration produced equal bronchodilatation. Intravenous salbutamol caused significant increases in plasma insulin and glucose levels and a fall in serum potassium concentration in addition to tachycardia and tremor, whereas aerosol salbutamol produced only a small transient increase in the plasma glucose level. The initially raised non-esterified fatty acid levels decreased significantly after aerosol and placebo but not after intravenous salbutamol.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Collins J. M., McDevitt D. G., Shanks R. G., Swanton J. G. The cardio-toxicity of isoprenaline during hypoxia. Br J Pharmacol. 1969 May;36(1):35–45. doi: 10.1111/j.1476-5381.1969.tb08301.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gelband H., Bush H. L., Rosen M. R., Myerburg R. J., Hoffman B. F. Electrophysiologic properties of isolated preparations of human atrial myocardium. Circ Res. 1972 Mar;30(3):293–300. doi: 10.1161/01.res.30.3.293. [DOI] [PubMed] [Google Scholar]
- HOFFMAN B. F., CRANEFIELD P. F. THE PHYSIOLOGICAL BASIS OF CARDIAC ARRHYTHMIAS. Am J Med. 1964 Nov;37:670–684. doi: 10.1016/0002-9343(64)90017-8. [DOI] [PubMed] [Google Scholar]
- Inoue S. Effects of epinephrine on asthmatic children. Effects of epinephrine on blood glucose, pulmonary function, and heart rate of children with asthma of varying severity. J Allergy. 1967 Dec;40(6):337–348. doi: 10.1016/0021-8707(67)90023-8. [DOI] [PubMed] [Google Scholar]
- Middleton E., Jr, Finke S. R. Metabolic response to epinephrine in bronchial asthma. J Allergy. 1968 Nov;42(5):288–299. doi: 10.1016/0021-8707(68)90022-1. [DOI] [PubMed] [Google Scholar]
- Oliver M. F. Metabolic response during impending myocardial infarction. II. Clinical implications. Circulation. 1972 Feb;45(2):491–500. doi: 10.1161/01.cir.45.2.491. [DOI] [PubMed] [Google Scholar]
- Opie L. H. Metabolic response during impending myocardial infarction. I. Relevance of studies of glucose and fatty acid metabolism in animals. Circulation. 1972 Feb;45(2):483–490. doi: 10.1161/01.cir.45.2.483. [DOI] [PubMed] [Google Scholar]
- Paterson J. W., Shenfield G. M. Bronchodilators. Part I. BTTA Rev. 1974 Jun;4(2):25–40. [PubMed] [Google Scholar]
- Taylor M. W., Gaddie J., Murchison L. E., Palmer K. N. Metabolic effects of oral salbutamol. Br Med J. 1976 Jan 3;1(6000):22–22. doi: 10.1136/bmj.1.6000.22. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wang P., Clausen T. Treatment of attacks in hyperkalaemic familial periodic paralysis by inhalation of salbutamol. Lancet. 1976 Jan 31;1(7953):221–223. doi: 10.1016/s0140-6736(76)91340-4. [DOI] [PubMed] [Google Scholar]