Abstract
Twelve subjects given therapeutic doses of carbamazepine showed no change in their plasma electrolyte concentrations. Ten of the 12 had abnormal water metabolism, however, their ability to excrete water loads being decreased. Plasma arginine vasopressin (AVP) concentrations fell while the subjects were taking the drug, indicating that the mechanism is unlikely to be increased secretion of antidiuretic hormone. We suggest that the water-retaining property of carbamazepine is a physiological effect of the drug, mediated by increased renal sensitivity to normal plasma concentrations of AVP and resetting of osmoreceptors.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baylis P. H., Heath D. A. The development of a radioimmunoassay for the measurement of human plasma arginine vasopressin. Clin Endocrinol (Oxf) 1977 Aug;7(2):91–102. doi: 10.1111/j.1365-2265.1977.tb01300.x. [DOI] [PubMed] [Google Scholar]
- Meinders A. E., Cejka V., Robertson G. L. The antidiuretic action of carbamazepine in man. Clin Sci Mol Med. 1974 Oct;47(4):289–299. doi: 10.1042/cs0470289. [DOI] [PubMed] [Google Scholar]