Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1977 Feb 26;1(6060):535–537. doi: 10.1136/bmj.1.6060.535

Preventing venous thromboembolism in elderly patients with hip fractures: studies of low-dose heparin, dipyridamole, aspirin, and flurbiprofen.

G K Morris, J R Mitchell
PMCID: PMC1605162  PMID: 843794

Abstract

Low-dose heparin, dipyridamole (alone and in combination with aspirin), and flurbiprofen were evaluated as potential prophylactic agents against deep venous thrombosis in elderly patients with hip fractures. None of the agents that modify platelet behaviour could reduct the frequency of isotopically diagnosed venous thrombosis. Low-dose heparin reduced the overall frequency of venous thrombosis and its extent as judged by the frequency of bilaterally abnormal scans, but this reduction did not achieve statistical significance.

Full text

PDF
535

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Browse N. L., Hall J. H. Effect of dipyridamole on the incidence of clinically detectable deep-vein thrombosis. Lancet. 1969 Oct 4;2(7623):718–720. doi: 10.1016/s0140-6736(69)90429-2. [DOI] [PubMed] [Google Scholar]
  2. Emmons P. R., Harrison M. J., Honour A. J., Mitchell J. R. Effect of a pyrimidopyrimidine derivative on thrombus formation in the rabbit. Nature. 1965 Oct 16;208(5007):255–257. doi: 10.1038/208255a0. [DOI] [PubMed] [Google Scholar]
  3. Emmons P. R., Harrison M. J., Honour A. J., Mitchell J. R. Effect of dipyridamole on human platelet behaviour. Lancet. 1965 Sep 25;2(7413):603–606. doi: 10.1016/s0140-6736(65)90515-5. [DOI] [PubMed] [Google Scholar]
  4. Gallus A. S., Hirsh J., Tutle R. J., Trebilcock R., O'Brien S. E., Carroll J. J., Minden J. H., Hudecki S. M. Small subcutaneous doses of heparin in prevention of venous thrombosis. N Engl J Med. 1973 Mar 15;288(11):545–551. doi: 10.1056/NEJM197303152881103. [DOI] [PubMed] [Google Scholar]
  5. Harker L. A., Slichter S. J. Studies of platelet and fibrinogen kinetics in patients with prosthetic heart valves. N Engl J Med. 1970 Dec 10;283(24):1302–1305. doi: 10.1056/NEJM197012102832402. [DOI] [PubMed] [Google Scholar]
  6. Kakkar V. V., Corrigan T., Spindler J., Fossard D. P., Flute P. T., Crellin R. Q., Wessler S., Yin E. T. Efficacy of low doses of heparin in prevention of deep-vein thrombosis after major surgery. A double-blind, randomised trial. Lancet. 1972 Jul 15;2(7768):101–106. doi: 10.1016/s0140-6736(72)91595-4. [DOI] [PubMed] [Google Scholar]
  7. Lindsay R. M., Ferguson D., Prentice C. R., Burton J. A., McNicol G. P. Reduction of thrombus formation on dialyser membranes by aspirin and RA 233. Lancet. 1972 Dec 16;2(7790):1287–1290. doi: 10.1016/s0140-6736(72)92656-6. [DOI] [PubMed] [Google Scholar]
  8. Morris G. K., Henry A. P., Preston B. J. Prevention of deep-vein thrombosis by low-dose heparin in patients undergoing total hip replacement. Lancet. 1974 Oct 5;2(7884):797–800. doi: 10.1016/s0140-6736(74)91069-1. [DOI] [PubMed] [Google Scholar]
  9. Morris G. K., Mitchell J. R. Prevention and diagnosis of venous thrombosis in patients with hip fractures. A survey of current practice. Lancet. 1976 Oct 23;2(7991):867–869. doi: 10.1016/s0140-6736(76)90535-3. [DOI] [PubMed] [Google Scholar]
  10. Nicolaides A. N., Dupont P. A., Desai S., Lewis J. D., Douglas J. N., Dodsworth H., Fourides G., Luck R. J., Jamieson C. W. Small doses of subcutaneous sodium heparin in preventing deep venous thrombosis after major surgery. Lancet. 1972 Oct 28;2(7783):890–893. doi: 10.1016/s0140-6736(72)92531-7. [DOI] [PubMed] [Google Scholar]
  11. O'Brien J. R. Effects of salicylates on human platelets. Lancet. 1968 Apr 13;1(7546):779–783. doi: 10.1016/s0140-6736(68)92228-9. [DOI] [PubMed] [Google Scholar]
  12. Renney J. T., O'Sullivan E. F., Burke P. F. Prevention of postoperative deep vein thrombosis with dipyridamole and aspirin. Br Med J. 1976 Apr 24;1(6016):992–994. doi: 10.1136/bmj.1.6016.992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. SEVITT S., GALLAGHER N. G. Prevention of venous thrombosis and pulmonary embolism in injured patients. A trial of anticoagulant prophylaxis with phenindione in middle-aged and elderly patients with fractured necks of femur. Lancet. 1959 Dec 5;2(7110):981–989. doi: 10.1016/s0140-6736(59)91464-3. [DOI] [PubMed] [Google Scholar]
  14. Salzman E. W., Harris W. H., DeSanctis R. W. Reduction in venous thromboembolism by agents affecting platelet function. N Engl J Med. 1971 Jun 10;284(23):1287–1292. doi: 10.1056/NEJM197106102842303. [DOI] [PubMed] [Google Scholar]
  15. Wessler S., Yin E. T. Theory and practice of minidose heparin in surgical patients. A status report. Circulation. 1973 Apr;47(4):671–676. doi: 10.1161/01.cir.47.4.671. [DOI] [PubMed] [Google Scholar]
  16. Zucker M. B., Peterson J. Inhibition of adenosine diphosphate-induced secondary aggregation and other platelet functions by acetylsalicylic acid ingestion. Proc Soc Exp Biol Med. 1968 Feb;127(2):547–551. doi: 10.3181/00379727-127-32737. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES