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. 1977 Mar 5;1(6061):607–610. doi: 10.1136/bmj.1.6061.607

Metronidazole in prevention and treatment of bacteroides infections in elective colonic surgery.

A T Willis, I R Ferguson, P H Jones, K D Phillips, P V Tearle, R V Fiddian, D F Graham, D H Harland, D F Hughes, D Knight, W M Mee, N Pashby, R L Rothwell-Jackson, A K Sachdeva, I Sutch, C Kilbey, D Edwards
PMCID: PMC1605270  PMID: 321076

Abstract

A double-blind randomised trial was carried out among 46 patients undergoing elective colonic surgery; 27 patients received prophylactic metronidazole and 19 received placebo. Anaerobic infections did not develop in any of the metronidazole-treated patients, but did develop in 11 (58%) of 19 controls who were subsequently successfully treated with metronidazole.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Davidson A. I., Smith G., Smylie H. G. A bacteriological study of the immediate environment of a surgical wound. Br J Surg. 1971 May;58(5):326–333. doi: 10.1002/bjs.1800580503. [DOI] [PubMed] [Google Scholar]
  2. Everett M. T., Brogan T. D., Nettleton J. The place of antibiotics in colonic surgery: a clinical study. Br J Surg. 1969 Sep;56(9):679–684. doi: 10.1002/bjs.1800560911. [DOI] [PubMed] [Google Scholar]
  3. Goldring J., McNaught W., Scott A., Gillespie G. Prophylactic oral antimicrobial agents in elective colonic surgery. A controlled trial. Lancet. 1975 Nov 22;2(7943):997–1000. doi: 10.1016/s0140-6736(75)90289-5. [DOI] [PubMed] [Google Scholar]
  4. Griffiths D. A., Simpson R. A., Shorey B. A., Speller D. C., Williams N. B. Single-dose peroperative antibiotic prophylaxis in gastrointestinal surgery. Lancet. 1976 Aug 14;2(7981):325–328. doi: 10.1016/s0140-6736(76)92588-5. [DOI] [PubMed] [Google Scholar]
  5. Jackson D. W., Pollock A. V., Tindal D. S. The value of a plastic adhesive drape in the prevention of wound infection. A controlled trial. Br J Surg. 1971 May;58(5):340–342. doi: 10.1002/bjs.1800580506. [DOI] [PubMed] [Google Scholar]
  6. Keighley M. R., Crapp A. R., Burdon D. W., Cooke W. T., Alexander-Williams J. Prophylaxis against anaerobic sepsis in bowel surgery. Br J Surg. 1976 Jul;63(7):538–541. doi: 10.1002/bjs.1800630711. [DOI] [PubMed] [Google Scholar]
  7. Leigh D. A., Simmons K., Norman E. Bacterial flora of the appendix fossa in appendicitis and postoperative wound infection. J Clin Pathol. 1974 Dec;27(12):997–1000. doi: 10.1136/jcp.27.12.997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Leigh D. A. Wound infections due to Bacteroides fragilis following intestinal surgery. Br J Surg. 1975 May;62(5):375–378. doi: 10.1002/bjs.1800620512. [DOI] [PubMed] [Google Scholar]
  9. Nichols R. L., Broido P., Condon R. E., Gorbach S. L., Nyhus L. M. Effect of preoperative neomycin-erythromycin intestinal preparation on the incidence of infectious complications following colon surgery. Ann Surg. 1973 Oct;178(4):453–462. doi: 10.1097/00000658-197310000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Phillips K. D., Tearle P. V., Willis A. T. Rapid diagnosis of anaerobic infections by gas-liquid chromatography of clinical material. J Clin Pathol. 1976 May;29(5):428–432. doi: 10.1136/jcp.29.5.428. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Stokes E. J., Waterworth P. M., Franks V., Watson B., Clark C. G. Short term routine antibiotic prophylaxis in surgery. Br J Surg. 1974 Sep;61(9):739–742. doi: 10.1002/bjs.1800610917. [DOI] [PubMed] [Google Scholar]

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