Abstract
In a case of quinine-induced agranulocytosis marrow culture studies confirmed the inhibitory effect on the patient's cells of equivalent therapeutic plasma concentrations of quinine. Similar concentrations had no effect on normal marrow cells. Quinidine, the stereoisomer of quinine, had no effect on either cells from the patient or normal cells. The results encourage the use of in-vitro bone marrow cultures for identifying drugs responsible for agranulocytosis.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Howell A., Chinn S., Andrews T. M., Watts R. W. The effects of drugs that cause neutropenia upon colony formation by bone marrow cells in semi-solid agar. Clin Sci Mol Med. 1974 May;46(5):619–628. doi: 10.1042/cs0460619. [DOI] [PubMed] [Google Scholar]
- Lind D. E., Levi J. A., Vincent P. C. Amodiaquine-induced agranulocytosis: toxic effect of amodiaquine in bone marrow cultures in vitro. Br Med J. 1973 Feb 24;1(5851):458–460. doi: 10.1136/bmj.1.5851.458. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ratzan R. J., Moore M. A., Yunis A. A. Effect of chloramphenicol and thiamphenicol on the in vitro colony-forming cell. Blood. 1974 Mar;43(3):363–369. [PubMed] [Google Scholar]