Abstract
Norethisterone oenanthate (NET-OEN) was given as an injectable contraceptive to 295 healthy women over 1606 woman-months. A modified injection schedule was used. There were no pregnancies, and the 12-month, life-table, use-related discontinuation rate was 39.1/100 users. Menstrual disturbance (10.8/100 women), minor side effects (13.5/100 women), and personal reasons (12.0/100 women) were the main causes of use-related discontinuation. There was no difference in use-related discontinuation rates between women receiving their first injection during a normal menstrual period and those receiving it immediately after a pregnancy. There were no serious side effects. The use of NET-OEN in certain groups of women is recommended, particularly in those in need of highly effective contraception, who cannot or do not wish to take oral contraceptives, who are lactating, or who are awaiting hospital admission for sterilisation.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Coutinho E. M., de Souza J. C., Csapo A. I. Reversible sterility induced by medroxyprogesterone injections. Fertil Steril. 1966 Mar-Apr;17(2):261–266. doi: 10.1016/s0015-0282(16)35893-9. [DOI] [PubMed] [Google Scholar]
- Howard G., Myatt L., Elder M. G. The effects of intramuscular norethisterone oenanthate used as a contraceptive on intravenous glucose tolerance and on blood coagulation factors VII and X. Br J Obstet Gynaecol. 1977 Aug;84(8):618–621. doi: 10.1111/j.1471-0528.1977.tb12665.x. [DOI] [PubMed] [Google Scholar]
- Howard G., Warren R. J., Fotherby K. Plasma levels of norethisterone in women receiving norethisterone oenanthate intramuscularly. Contraception. 1975 Jul;12(1):45–52. doi: 10.1016/s0010-7824(75)80035-7. [DOI] [PubMed] [Google Scholar]
- Kesserü-Koós E., Larrañaga-Legufa A., Hurtado-Koo H., Scharff H. J. Fertility control with norethindrone enanthate, a long-acting parenteral progestogen. Acta Eur Fertil. 1973 Dec;4(4):203–221. [PubMed] [Google Scholar]
- SIEGEL I. Conception control by long-acting progestogens: preliminary report. Obstet Gynecol. 1963 Jun;21:666–668. [PubMed] [Google Scholar]
- Weiner E., Johansson E. D. The influence of norethisterone oenanthate on ovarian function. Acta Endocrinol (Copenh) 1976 Oct;83(2):386–392. doi: 10.1530/acta.0.0830386. [DOI] [PubMed] [Google Scholar]
- el-Mahgoub S., Karim M., Ammar R. Long-term use of depot medroxy progesterone acetate as a contraceptive. Acta Obstet Gynecol Scand. 1972;51(3):251–255. doi: 10.3109/00016347209156855. [DOI] [PubMed] [Google Scholar]
- el-Mahgoub S., Karim M. The long-term use of injectable norethisterone enanthate as a contraceptive. Contraception. 1972 Jan;5(1):21–29. doi: 10.1016/0010-7824(72)90077-7. [DOI] [PubMed] [Google Scholar]