Abstract
Hospital admissions due to acute barbiturate poisoning per million population in England and Wales have decreased since 1965 at about the same rate as NHS prescriptions for barbiturates. Admissions due to poisoning with other drugs have increased, but, largely because the benzodiazepine hypnotics and tranquillisers are much less toxic than the barbiturates that they are replacing, deaths from poisoning with all solids and liquids have decreased. The risk of death from self-poisoning associated with each barbiturate prescription has increased two and a half times since 1961, perhaps partly because greater quantities of barbiturate are being dispensed with each prescription and partly because patients for whom these drugs are still being prescribed would, in the event of an overdose, be unlikely to be found and admitted to hospital in time owing to their age and social circumstances. There is now little to justify prescribing barbiturate hypnotics or sedatives for anyone.
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Selected References
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- Adam K., Adamson L., Brezinová V., Hunter W. M. Nitrazepam: lastingly effective but trouble on withdrawal. Br Med J. 1976 Jun 26;1(6025):1558–1560. doi: 10.1136/bmj.1.6025.1558. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barraclough B. M. Are there safer hypnotics than barbiturates? Lancet. 1974 Jan 12;1(7846):57–58. doi: 10.1016/s0140-6736(74)93055-4. [DOI] [PubMed] [Google Scholar]
- Barraclough B. M., Pallis D. J. Depression followed by suicide: a comparison of depressed suicides with living depressives. Psychol Med. 1975 Feb;5(1):55–61. doi: 10.1017/s0033291700007212. [DOI] [PubMed] [Google Scholar]
- Berger F. M. Drugs and suicide in the United States. Clin Pharmacol Ther. 1967 Mar-Apr;8(2):219–223. doi: 10.1002/cpt196782219. [DOI] [PubMed] [Google Scholar]
- Kales A., Kales J. D., Bixler E. O., Scharf M. B. Effectiveness of hypnotic drugs with prolonged use: flurazepam and pentobarbital. Clin Pharmacol Ther. 1975 Sep;18(3):356–363. doi: 10.1002/cpt1975183356. [DOI] [PubMed] [Google Scholar]
- Kreitman N. The coal gas story. United Kingdom suicide rates, 1960-71. Br J Prev Soc Med. 1976 Jun;30(2):86–93. doi: 10.1136/jech.30.2.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Trethowan W. H. Pills for personal problems. Br Med J. 1975 Sep 27;3(5986):749–751. doi: 10.1136/bmj.3.5986.749. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wells F. O. Prescribing barbiturates: drug substitution in general practice. J R Coll Gen Pract. 1973 Mar;23(128):164–167. [PMC free article] [PubMed] [Google Scholar]