Skip to main content
NCBI home page
British Medical Journal logoLink to British Medical Journal
. 1978 Aug 19;2(6136):533–535. doi: 10.1136/bmj.2.6136.533

Haemostatic defect in non-immune patients with falciparum malaria: no evidence of diffuse intravascular coagulation.

J Vreeken, T M Cremer-Goote
PMCID: PMC1606951  PMID: 359086

Abstract

Nine non-immune patients with imported falciparum malaria were examined for signs of diffuse intravascular coagulation (DIC). Although all had thrombocytopenia initially and some later had a decline in plasma fibrinogen concentrations, DIC was never detected, even in severely affected patients with coma and kidney damage. None of the patients were given heparin and all recovered without residual symptoms. Heparin administration should probably be considered only when clear-cut DIC, which possibly never occurs in falciparum malaria, has been demonstrated.

Full text

PDF
533

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Areekul S. Coagulation and fibrinolysis in malaria. J Med Assoc Thai. 1972 Jul;55(7):389–394. [PubMed] [Google Scholar]
  2. Borochovitz D., Crosley A. L., Metz J. Disseminated intravascular coagulation with fatal haemorrhage in cerebral malaria. Br Med J. 1970 Jun 20;2(5711):710–710. doi: 10.1136/bmj.2.5711.710. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Butler T., Tong M. J., Fletcher J. R., Dostalek R. J., Robbins T. O. Blood coagulation studies in Plasmodium falciparum malaria. Am J Med Sci. 1973 Jan;265(1):63–67. doi: 10.1097/00000441-197301000-00006. [DOI] [PubMed] [Google Scholar]
  4. Conrad M. E. Pathophysiology of malaria. Hematologic observations in human and animal studies. Ann Intern Med. 1969 Jan;70(1):134–141. doi: 10.7326/0003-4819-70-1-134. [DOI] [PubMed] [Google Scholar]
  5. Dennis L. H., Eichelberger J. W., Inman M. M., Conrad M. E. Depletion of coagulation factors in drug-resistant Plasmodium falciparum malaria. Blood. 1967 May;29(5):713–721. [PubMed] [Google Scholar]
  6. Devakul K., Harinasuta T., Reid H. A. 125-I-labelled fibrinogen in cerebral malaria. Lancet. 1966 Oct 22;2(7469):886–888. doi: 10.1016/s0140-6736(66)91982-9. [DOI] [PubMed] [Google Scholar]
  7. Gerrits W. B., Prakke E. M., van der Meer J., Vreeken J. Causes of a negative ethanol gelation test in diffuse intravascular coagulation. Thromb Diath Haemorrh. 1974 May 15;31(2):299–308. [PubMed] [Google Scholar]
  8. Godal H. C., Abildgaard U. Gelation of soluble fibrin in plasma by ethanol. Scand J Haematol. 1966;3(5):342–350. doi: 10.1111/j.1600-0609.1966.tb02378.x. [DOI] [PubMed] [Google Scholar]
  9. Hall A. P. The treatment of malaria. Br Med J. 1976 Feb 7;1(6005):323–328. doi: 10.1136/bmj.1.6005.323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jaroonvesama N., Harinasuta T., Muangmanee L., Asawapokee N. Coagulation studies in falciparum and vivax malaria. Southeast Asian J Trop Med Public Health. 1975 Sep;6(3):419–424. [PubMed] [Google Scholar]
  11. Jaroonvesama N. Intravascular coagulation in falciparum malaria. Lancet. 1972 Jan 29;1(7744):221–223. doi: 10.1016/s0140-6736(72)90621-6. [DOI] [PubMed] [Google Scholar]
  12. Meyer-Breiting E., Zimmermann H. Zur intravaskulären Koagulation bei zerebraler Malaria. Zentralbl Allg Pathol. 1975;119(4):286–293. [PubMed] [Google Scholar]
  13. Neva F. A., Sheagren J. N., Shulman N. R., Canfield C. J. Malaria: host-defense mechanisms and complications. Ann Intern Med. 1970 Aug;73(2):295–306. doi: 10.7326/0003-4819-73-2-295. [DOI] [PubMed] [Google Scholar]
  14. Paar D., Konig E., Fonk I., Brittinger G. Cerebral malaria and intravascular coagulation. Br Med J. 1970 Dec 26;4(5738):805–805. doi: 10.1136/bmj.4.5738.805-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Punyagupta S., Srichaikul T., Nitiyanant P., Petchclai B. Acute pulmonary insufficiency in falciparum malaria: summary of 12 cases with evidence of disseminated intravascular coagulation. Am J Trop Med Hyg. 1974 Jul;23(4):551–559. doi: 10.4269/ajtmh.1974.23.551. [DOI] [PubMed] [Google Scholar]
  16. Reid H. A. Letter: Adjuvant treatment of severe falciparum malaria, intravascular coagulation, and heparin. Lancet. 1975 Jan 18;1(7899):167–168. doi: 10.1016/s0140-6736(75)91469-5. [DOI] [PubMed] [Google Scholar]
  17. STORMORKEN H. The preparation of proaccelerin deficient (parahemophilia) plasma for the assay of proaccelerin. Scand J Clin Lab Invest. 1957;9(3):273–276. doi: 10.3109/00365515709079970. [DOI] [PubMed] [Google Scholar]
  18. STRENGERS T., ASBERG E. G. EEN SCREENING-TEST, GEVOLGD DOOR EEN SNELLE KWANTITATIEVE MICROBEPALING VAN FIBRINOGEEN IN PLASMA. Ned Tijdschr Geneeskd. 1963 Nov 2;107:2044–2045. [PubMed] [Google Scholar]
  19. Smitskamp H., Wolthuis F. H. New concepts in treatment of malignant tertian malaria with cerebral involvement. Br Med J. 1971 Mar 27;1(5751):714–716. doi: 10.1136/bmj.1.5751.714. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Van Aken W. G., Vreeken J. Accumulaon of macromolecular particles in the reticuloendothelial system (RES) mediated by platelet aggregation and disaggregation. Thromb Diath Haemorrh. 1969 Dec 31;22(3):496–507. [PubMed] [Google Scholar]
  21. van Aken W. G., Goote T. M., Vreeken J. Platelet aggregation: an intermediary mechanism in carbon clearance. Scand J Haematol. 1968;5(5):333–338. doi: 10.1111/j.1600-0609.1968.tb01757.x. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES